TGF-β signaling and the interaction between platelets and T-cells in tumor microenvironment: Foes or friends?

被引：8
|
作者：
Razavi, Azadeh Sadat [1 ,2 ]
Mohtashami, Maryam [2 ,3 ]
Razi, Sepideh [1 ,2 ,4 ]
Rezaei, Nima [2 ,5 ,6 ]
机构：
[1] Universal Sci Educ & Res Network USERN, Canc Immunol Project CIP, Tehran, Iran
[2] Univ Tehran Med Sci, Res Ctr Immunodeficiencies, Childrens Med Ctr, Tehran, Iran
[3] High Inst Res & Educ Transfus Med, Blood Transfus Res Ctr, Tehran, Iran
[4] Iran Univ Med Sci, Sch Med, Tehran, Iran
[5] Univ Tehran Med Sci, Sch Med, Dept Immunol, Tehran, Iran
[6] Universal Sci Educ & Res Network USERN, Canc Immunol Project CIP, Stockholm, Sweden
来源：
CYTOKINE | 2022年 / 150卷
关键词：
Platelets; T-cells; Cancer; Transforming growth factor beta (TGF beta); GROWTH-FACTOR-BETA; GENE-MUTATIONS; CANCER; ACTIVATION; DIFFERENTIATION; CD4(+)CD25(+); INFLAMMATION; LYMPHOCYTES; METASTASIS; EXPRESSION;
D O I：
10.1016/j.cyto.2021.155772
中图分类号：
Q5 [生物化学]; Q7 [分子生物学];
学科分类号：
071010 ; 081704 ;
摘要：
T-cells, as the main immune cells in fighting against cancer cells, are usually overwhelmed by many factors. Tumor microenvironment (TME) changes are one of the factors that can limit T-cells functions. On the other hand, platelets which are known as the main source of transforming growth factor-beta (TGF-beta) in TME, are seemingly insignificant immune cells that can affect T-cell functions. There is a hypothesis that platelets might prevent tumor growth by stimulating cellular immunity, especially T-cells in pre-cancer status while they can inhibit T-cells and stimulate tumor growth in the advanced stage of cancer. Therefore, platelets could act as a double-edged sword in the activation of T-cells under pre-cancer and advanced stages of cancer conditions. In this review, the interaction between platelets and T cells in pre-cancer and advanced stages of cancer and the role of TGF-beta signaling in different stages of cancer will be discussed.
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页数：7
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