In vitro evaluation of the antimicrobial activity of meropenem in combination with polymyxin B and gatifloxacin against Pseudomonas aeruginosa and Acinetobacter baumannii

被引：19
|
作者：
Guelfi, K. C. [1 ]
Tognim, M. C. B. [1 ]
Cardoso, C. L. [1 ]
Gales, A. C. [2 ]
Carrara-Marrone, F. E. [3 ]
Garcia, L. B. [1 ]
机构：
[1] Univ Estadual Maringa, Dept Clin Analyses, BR-87020900 Maringa, Parana, Brazil
[2] Univ Fed Sao Paulo, Div Infect Dis, Sao Paulo, Brazil
[3] Univ Estadual Londrina, Dept Pathol Clin & Toxicol Analyses, Londrina, Parana, Brazil
来源：
JOURNAL OF CHEMOTHERAPY | 2008年 / 20卷 / 02期
关键词：
Acinetobacter baumannii; Pseudomonas aeruginosa; meropenem; polymyxin B; gatifloxacin;
D O I：
10.1179/joc.2008.20.2.180
中图分类号：
R73 [肿瘤学];
学科分类号：
100214 ;
摘要：
The antimicrobial activity of meropenem combined with either polymyxin B or gatifloxacin was evaluated by the checkerboard method against Pseudomonas aeruginosa (10 strains) and Acinetobacter baumannii (10 strains). In addition, the triple combination of polymyxin B, gatifloxacin, and meropenem was also studied as well as the polymyxin B and gatifloxacin combination. A partial synergism interaction between meropenem and polymyxin B was observed for 80% of the A. baumannii strains. In contrast, this combination showed an indifferent effect for 80% of the P. aeruginosa strains tested. The combination of meropenem and gatifloxacin showed synergism only for two strains of A. baumannii, and partial synergism and additive effect for seven strains and indifference for four strains of both species. For the strains of P. aeruginosa, the double combination of polymyxin B and gatifloxacin and the triple combination of meropenem, polymyxin B and gatifloxacin were indifferent for the majority of the strains tested, that is, 90 and 80% respectively.
引用
收藏
页码：180 / 185
页数：6
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