A novel artificial superoxide dismutase: Non-covalent conjugation of albumin with a MnIII salophen type complex

被引：35

作者：

Oliveri, Valentina ^{[1
]}

Vecchio, Graziella ^{[1
]}

机构：

[1] Univ Catania, Dipartimento Sci Chim, I-95125 Catania, Italy

来源：

EUROPEAN JOURNAL OF MEDICINAL CHEMISTRY | 2011年 / 46卷 / 03期

关键词：

SOD mimics; Manganese(III) complexes; BSA; CD; OXIDATIVE STRESS; NITRIC-OXIDE; BINDING; PHTHALOCYANINE; PROTECTION; MIMETICS; EUK-134; MICE;

D O I：

10.1016/j.ejmech.2010.12.023

中图分类号：

R914 [药物化学];

学科分类号：

100701 ;

摘要：

The approach of non-covalent conjugation has recently been used and a number of metal complexes have been encaged in a protein scaffold to form functional metallo proteins. Here we investigate a novel artificial superoxide dismutase enzyme based on the non-covalent conjugation of bovine serum albumin and the manganese(III) complex of N,N'-bis(salicylidene)-3,4-diaminobenzoic acid. We report the intriguing ability of the albumin environment to increase the SOD activity of the inorganic complex. We also determined the binding constant with BSA by CD spectroscopy. (C) 2011 Elsevier Masson SAS. All rights reserved.

引用

页码：961 / 965

页数：5

共 18 条

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