Hyperpolarized helium-3 magnetic resonance lung imaging of non-sedated infants and young children: a proof-of-concept study

被引：30
|
作者：
Altes, Talissa A. [1 ,2 ]
Meyer, Craig H. [2 ,3 ]
Mata, Jaime F. [2 ]
Froh, Deborah K. [4 ]
Paget-Brown, Alix [4 ]
Teague, W. Gerald [4 ]
Fain, Sean B. [5 ]
de Lange, Eduard E. [2 ]
Ruppert, Kai [7 ]
Botfield, Martyn C. [6 ]
Johnson, Mac A. [6 ]
Mugler, John. P., III [2 ,3 ]
机构：
[1] Univ Missouri, Dept Radiol, Columbia, MO USA
[2] Univ Virginia, Dept Radiol & Med Imaging, Charlottesville, VA USA
[3] Univ Virginia, Dept Biomed Engn, Charlottesville, VA USA
[4] Univ Virginia, Dept Pediat, Charlottesville, VA USA
[5] Univ Wisconsin, Dept Med Phys & Radiol, Madison, WI USA
[6] Vertex Pharmaceut Inc, Boston, MA USA
[7] Univ Penn, Dept Radiol, Philadelphia, PA 19104 USA
来源：
CLINICAL IMAGING | 2017年 / 45卷
关键词：
Hyperpolarized helium MRI; Cystic fibrosis; Magnetic resonance imaging; Child; Infant; AIR-FLOW OBSTRUCTION; CYSTIC-FIBROSIS; MRI; ASTHMA; SPIROMETRY; DISEASE; RECONSTRUCTION; PERSPECTIVE; GAS; CT;
D O I：
10.1016/j.clinimag.2017.04.004
中图分类号：
R8 [特种医学]; R445 [影像诊断学];
学科分类号：
1002 ; 100207 ; 1009 ;
摘要：
Purpose: To develop and evaluate a protocol for hyperpolarized helium-3 (HHe) ventilation magnetic resonance imaging (MRI) of the lungs of non-sedated infants and children. Materials and methods: HHe ventilation MRI was performed on seven children <= 4years old. Contiguous 2D-spiral helium-3 images were acquired sequentially with a scan time of <= 0.2 s/slice. Results: Motion-artifact-free, high signal-to-noise ratio (SNR) images of lung ventilation were obtained. Gas was homogeneously distributed in healthy individuals; focal ventilation defects were found in patients with respiratory diseases. Conclusion: HHe ventilation MRI can aid assessment of pediatric lung disease even at a young age. (C) 2017 The Authors. Published by Elsevier Inc.
引用
收藏
页码：105 / 110
页数：6
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