AMP-Deaminase from Thymus of Patients with Myasthenia Gravis

被引:1
|
作者
Rybakowska, I. [1 ]
Szydlowska, M. [1 ]
Szrok, S. [2 ]
Bakula, S. [3 ]
Kaletha, K. [1 ]
机构
[1] Med Univ Gdansk, Dept Biochem & Clin Physiol, PL-80211 Gdansk, Poland
[2] Med Univ Gdansk, Dept Biochem, PL-80211 Gdansk, Poland
[3] Med Univ Gdansk, Dept Rehabil, PL-80211 Gdansk, Poland
来源
关键词
human thymus; AMP-deaminase; Myasthenia gravis; ADENYLATE DEAMINASE; DEFICIENCY; ENZYMES;
D O I
10.1080/15257770.2014.978940
中图分类号
Q5 [生物化学]; Q7 [分子生物学];
学科分类号
071010 ; 081704 ;
摘要
Myasthenia gravis (MG) is characterized clinically by skeletal muscle fatigue following the excessive exercise. Interestingly most of MG patients manifest parallely also some abnormalities of the thymus.AMP-deaminase (AMPD) from human thymus was not a subject of studies up to now. In this paper, mRNA expression and some physico-chemical and immunological properties of AMPD purified from the thymus of MG patients were described. Experiments performed identified the liver isozyme (AMPD2) as the main isoform of AMPD expressed in this organ. The activity of AMPD found in this organ was higher than in other human non-(skeletal) muscle tissues indicating on role the enzyme may play in supplying of guanylates required for the intensive multiplication of thymocytes.
引用
收藏
页码:229 / 234
页数:6
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