[3H]LY341495, a highly potent, selective and novel radioligand for labeling group II metabotropic glutamate receptors

被引：40
|
作者：
Ornstein, PL [1 ]
Arnold, MB [1 ]
Bleisch, TJ [1 ]
Wright, RA [1 ]
Wheeler, WJ [1 ]
Schoepp, DD [1 ]
机构：
[1] Eli Lilly & Co, Lilly Res Labs, Lilly Corp Ctr, Indianapolis, IN 46285 USA
来源：
BIOORGANIC & MEDICINAL CHEMISTRY LETTERS | 1998年 / 8卷 / 14期
关键词：
D O I：
10.1016/S0960-894X(98)00329-1
中图分类号：
R914 [药物化学];
学科分类号：
100701 ;
摘要：
We report herein the synthesis and pharmacological characterization of a tritiated version of the potent and selective cyclopropyl amino acid LY341495 as a radioligand to label group II metabotropic glutamate receptors in rat brain homogenates. (C) 1998 Elsevier Science Ltd. All rights reserved.
引用
收藏
页码：1919 / 1922
页数：4
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