Mesospaced surface for DNA microarray and other applications

We have Studied ways to control density as well as spacing among functional groups. In particular, we observed that use of aziridine for the Surface hyperbranching polymerization yielded extremely high surface density of primary amine that is useful for the immobilization of molecules of biological relevance Such as oligo DNA. Also, an employment of dendrons of appropriate molecular architecture provided mesospacing among the reactive functional groups. The spacings was expected to guarantee the freedom of the biological macromolecules so that their properties are close to that in Solution in spite of the confinement in the two dimensional world. We demonstrated that this was the case for oligonucleotide microarrays.