An update on the role of adipokines in arterial stiffness and hypertension

被引：44
|
作者：
Sabbatini, Andrea R. [1 ]
Fontana, Vanessa [1 ]
Laurent, Stephane [2 ,3 ]
Moreno, Heitor [1 ]
机构：
[1] Univ Estadual Campinas, UNICAMP, Fac Med Sci, Dept Pharmacol, BR-13083970 Campinas, SP, Brazil
[2] Paris Derscartes Univ, Hosp Europeen Georges Pompidou, Assistance Publ Hop Paris, Dept Pharmacol, Paris, France
[3] Paris Derscartes Univ, Hosp Europeen Georges Pompidou, Assistance Publ Hop Paris, INSERM,U970, Paris, France
来源：
JOURNAL OF HYPERTENSION | 2015年 / 33卷 / 03期
基金：
巴西圣保罗研究基金会;
关键词：
adipokines; arterial stiffness; hypertension; HIGH-MOLECULAR-WEIGHT; PULSE-WAVE VELOCITY; C-REACTIVE PROTEIN; SYSTOLIC BLOOD-PRESSURE; LOW-GRADE INFLAMMATION; FATTY-ACID OXIDATION; AORTIC STIFFNESS; RESISTANT HYPERTENSION; PLASMA ADIPONECTIN; ADIPOSE-TISSUE;
D O I：
10.1097/HJH.0000000000000444
中图分类号：
R6 [外科学];
学科分类号：
1002 ; 100210 ;
摘要：
Adipokines are hormones produced by adipocytes and have been involved in multiple pathologic pathways, including inflammatory and cardiovascular complications in essential hypertension. Arterial stiffness is a frequent vascular complication that represents increased cardiovascular risk in hypertensive patients. Adipokines, such as adiponectin, leptin and resistin, might be implicated in hypertension, as well as in vascular alterations associated with this condition. Arterial stiffness has proven to be a predictor of cardiovascular events. Obesity and target-organ damage such as arterial stiffness are features associated with hypertension. This review aims to update the association between adipokines and arterial stiffness in essential and resistant hypertension (RHTN).
引用
收藏
页码：435 / 444
页数：10
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