Does the neuropsychiatric inventory predict progression from mild cognitive impairment to dementia? A systematic review and meta-analysis

被引：21
|
作者：
Mallo, Sabela C. [1 ]
Patten, Scott B. [2 ,3 ,5 ]
Ismail, Zahinoor [2 ,3 ,4 ,5 ]
Pereiro, Arturo X. [1 ]
Facal, David [1 ]
Otero, Carlos [1 ]
Juncos-Rabadan, Onesimo [1 ]
机构：
[1] Univ Santiago Compostela, Dept Dev Psychol, Xose Maria Suarez Nunez St,Campus Sur, Galicia 15782, ES, Spain
[2] Univ Calgary, Hotchkiss Brain Inst, 3330 Hosp Dr NW, Calgary, AB T2N 4N1, Canada
[3] Univ Calgary, Dept Psychiat, 2500 Univ Dr NW, Calgary, AB T2N 1N4, Canada
[4] Univ Calgary, Dept Clin Neurosci, 2500 Univ Dr NW, Calgary, AB T2N 1N4, Canada
[5] Mathison Ctr Mental Hlth Res & Educ, 3280 Hosp Dr NW, Calgary, AB T2N 4Z6, Canada
来源：
AGEING RESEARCH REVIEWS | 2020年 / 58卷
关键词：
Neuropsychiatric symptoms; Mild cognitive impairment; Dementia; Neuropsychiatric inventory; Neuropsychiatric inventory questionnaire; Meta-analysis; ALZHEIMERS-DISEASE; FASTER PROGRESSION; RATING-SCALE; SYMPTOMS; RISK; POPULATION; CONVERSION; MANIFESTATIONS; ASSOCIATION;
D O I：
10.1016/j.arr.2019.101004
中图分类号：
Q2 [细胞生物学];
学科分类号：
071009 ; 090102 ;
摘要：
Background Neuropsychiatric Symptoms (NPS) are common in Mild Cognitive Impairment (MCI). The Neuropsychiatric Inventory (NPI) and its shorter version, the Neuropsychiatric Inventory Questionnaire (NPI-Q), are the most common measures to assess NPS. Our objective was to determine if NPI/NPI-Q ratings predict conversion from MCI to dementia. Methods: Empirical longitudinal studies published in English or Spanish, concerned with the role of NPS as a risk factor for conversion from MCI to dementia, with a diagnosis of MCI following clinical criteria, that reported NPI/NPI-Q total score in converters versus non-converters, were included. Random effects models were used, and heterogeneity was explored with stratification and a random-effects meta-regression. The overall conversion rate and the standardized mean difference (SMD) for evolution, as a function of NPI/NPI-Q scores, were calculated. Results: The overall conversion rate was 35 %. Mean NPI/NPI-Q ratings were higher in converters versus in non converters, with the overall SMD approaching significance. Heterogeneity was observed in studies of more than two years of follow-up and in a study with a mean age of more than 80 years. This heterogeneity concerned the size, not the direction of the difference. Conclusions: Our results suggest that NPI/NPI-Q ratings are associated with conversion from MCI to dementia.
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页数：10
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