Overexpression of FAP7, MIG3, TMA19, or YLR392c confers resistance to arsenite on Saccharomyces cerevisiae

被引：12

作者：

Takahashi, Tsutomu ^{[1
]}

Yano, Toomi ^{[1
]}

Zhu, JunXuan ^{[1
]}

Hwang, Gi-Wook ^{[1
]}

Naganuma, Akira ^{[1
]}

机构：

[1] Tohoku Univ, Grad Sch Pharmaceut Sci, Lab Mol & Biochem Toxicol, Aoba Ku, Sendai, Miyagi 9808578, Japan

来源：

JOURNAL OF TOXICOLOGICAL SCIENCES | 2010年 / 35卷 / 06期

关键词：

Arsenite; Resistance; Yeast; Fap7; Mig3; YEAST;

D O I：

10.2131/jts.35.945

中图分类号：

R99 [毒物学（毒理学）];

学科分类号：

100405 ;

摘要：

To elucidate mechanisms of arsenic toxicity and biological defense mechanisms against arsenic, we searched for genes that, when overexpressed, conferred arsenite resistance on yeast. Employing a Saccharomyces cerevisiae open reading frame (ORF) library, four genes associated with arsenite resistance, PAP7, MIG3, TMA19, and YLR392c, were identified.

引用

页码：945 / 946

页数：2