Low vitamin B6 levels and the risk of recurrent venous thromboembolism

被引：19
|
作者：
Hron, Gregor [2 ]
Lombardi, Rossana [3 ]
Eichinger, Sabine [2 ]
Lecchi, Anna [3 ]
Kyrle, Paul A. [2 ]
Cattaneo, Marco [1 ]
机构：
[1] Univ Milan, Osped San Paolo, Dipartimento Med Chirurgia & Odontoiatria, Unita Ematol & Trombosi, Milan, Italy
[2] Med Univ Vienna, Dept Internal Med 1, Vienna, Austria
[3] Univ Milan, IRCCS Fdn Osped Maggiore Mangiagalli & Regina Ele, Dipartimento Med & Specialita Med, Milan, Italy
来源：
HAEMATOLOGICA | 2007年 / 92卷 / 09期
关键词：
deep vein thrombosis; risk factors; pulmonary embolism; homocysteine; vitamin B6;
D O I：
10.3324/haematol.11318
中图分类号：
R5 [内科学];
学科分类号：
1002 ; 100201 ;
摘要：
Low plasma vitamin B6, measured as pyridoxal-5'-phosphate (PLP), is associated with an increased risk of first venous thromboembolism (VTE). In a prospective cohort of 757 patients with first VTE we investigated the association of PLP levels with risk of recurrent VTE. After 4 years, the likelihood of VTE recurrence was 22.5% (95% CI 13.6-31.5%) among patients with PLP <= 23.3 nmol/L and 14.4% (11.5-17.4%) among those with PLP >23.3 nmol/L (p=0.01). Patients with PLP <= 23.3 nmol/L had 1.8-fold higher recurrence risk (1.01-3.14) than patients with PLP >23.3 nmol/L (adjusted for confounders including homocysteine). Therefore, low vitamin B6 is a risk factor of recurrent VTE.
引用
收藏
页码：1250 / 1253
页数：4
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