Ionic liquid mediated 1,3-dipolar cycloaddition of azomethine ylides: a facile and green synthesis of novel dispiro heterocycles

被引：54
|
作者：
Jain, Renuka [1 ]
Sharma, Kanti [1 ]
Kumar, Deepak [1 ]
机构：
[1] Univ Rajasthan, Dept Chem, Jaipur 302004, Rajasthan, India
来源：
TETRAHEDRON LETTERS | 2012年 / 53卷 / 15期
关键词：
1,3-Dipolar cycloaddition; Azomethine ylide; Spiro-oxindole; Ionic liquid; Environmentally benign; ONE-POT SYNTHESIS; STEREOSELECTIVE-SYNTHESIS; ASYMMETRIC-SYNTHESIS; MULTICOMPONENT SYNTHESIS; ISATIN; DERIVATIVES; ALKALOIDS; CATALYSIS;
D O I：
10.1016/j.tetlet.2012.02.029
中图分类号：
O62 [有机化学];
学科分类号：
070303 ; 081704 ;
摘要：
A greener, facile and efficient one-pot, three-component procedure for the synthesis of novel dispiropyrrolidine-bisoxindole derivatives by cycloaddition trapping of azomethine ylides generated in situ, via decarboxylative condensation of isatin with sarcosine (alpha-amino acid), has been reported in [bmim]PF6, an ionic liquid as a recyclable solvent in excellent yield without using any catalyst. This protocol provides mild reaction conditions, high yields of product in short reaction time, high regio- and stereoselectivity, operational simplicity and environmentally benign procedure. (C) 2012 Elsevier Ltd. All rights reserved.
引用
收藏
页码：1993 / 1997
页数：5
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