Mechanism of anti-HIV activity of dioxolane nucleosides against lamivudine-resistant HIV-1 reverse transcriptase-molecular modelling approach

被引：0
|
作者：
Chong, YH
Schinazi, RF
Chu, CK
机构：
[1] Univ Georgia, Coll Pharm, Athens, GA 30602 USA
[2] Emory Univ, Vet Affairs Med Ctr, Decatur, GA USA
来源：
ANTIVIRAL THERAPY | 2003年 / 8卷 / 03期
关键词：
D O I：
暂无
中图分类号：
R51 [传染病];
学科分类号：
100401 ;
摘要：
36
引用
收藏
页码：U46 / U47
页数：2
相关论文
共 50 条
  • [1] Mechanism of anti-HIV activity of dioxolane nuelcosides against 3TC-resistant HIV-1 reverse transcriptase-molecular modeling approach
    Chu, CK
    Schinazi, RF
    Chong, YH
    ANTIVIRAL RESEARCH, 2004, 62 (02) : A42 - A42
  • [2] Mechanism of anti-HIV activity of D4-nucleoside analogues against zidovudine- and lamivudine-resistant HIV-1 mutants: molecular modelling studies
    Chong, Y
    Choo, H
    Schinazi, RF
    Chu, CK
    ANTIVIRAL THERAPY, 2002, 7 : S33 - S33
  • [3] Long-Acting Anti-HIV Drugs Targeting HIV-1 Reverse Transcriptase and Integrase
    Singh, Kamal
    Sarafianos, Stefan G.
    Sonnerborg, Anders
    PHARMACEUTICALS, 2019, 12 (02)
  • [4] ASYMMETRIC-SYNTHESIS OF 1,3-DIOXOLANE PYRIMIDINE NUCLEOSIDES AND THEIR ANTI-HIV ACTIVITY
    KIM, HO
    AHN, SK
    ALVES, AJ
    BEACH, JW
    JEONG, LS
    CHOI, BG
    VANROEY, P
    SCHINAZI, RF
    CHU, CK
    JOURNAL OF MEDICINAL CHEMISTRY, 1992, 35 (11) : 1987 - 1995
  • [5] A POSSIBLE MECHANISM OF MOLECULAR RECOGNITION FOR THE REVERSE-TRANSCRIPTASE OF HIV-1
    NETO, JDD
    ZERNER, MC
    DEALENCASTRO, RB
    INTERNATIONAL JOURNAL OF QUANTUM CHEMISTRY, 1992, 44 (19) : 225 - 253
  • [6] Synthesis, anti-HIV activity, and metabolic stability of new alkenyldiarylmethane HIV-1 non-nucleoside reverse transcriptase inhibitors
    Deng, BL
    Hartman, TL
    Buckheit, RW
    Pannecouque, C
    De Clercq, E
    Fanwick, PE
    Cushman, M
    JOURNAL OF MEDICINAL CHEMISTRY, 2005, 48 (19) : 6140 - 6155
  • [7] Pyrimidine thioethers: A novel class of HIV-1 reverse transcriptase inhibitors with activity against BHAP-resistant HIV
    Nugent, RA
    Schlachter, ST
    Murphy, MJ
    Cleek, GJ
    Poel, TJ
    Wishka, DG
    Graber, DR
    Yagi, Y
    Keiser, BJ
    Olmsted, RA
    Kopta, LA
    Swaney, SM
    Poppe, SM
    Morris, J
    Tarpley, WG
    Thomas, RC
    JOURNAL OF MEDICINAL CHEMISTRY, 1998, 41 (20) : 3793 - 3803
  • [8] Nucleoside analogues targeted against nucleoside reverse transcriptase inhibitor-resistant HIV-1 reverse transcriptase
    Vu, B. C.
    Boyer, P. L.
    Siddiqui, M. A.
    Ambrose, Z.
    Marquez, V. E.
    Hughes, S. H.
    ANTIVIRAL THERAPY, 2008, 13 (04) : A37 - A37
  • [9] HIV-1 reverse transcriptase targeted for proteasomal degradation as a prototype vaccine against drug-resistant HIV-1
    Starodubova, Elizaveta
    Boberg, Andreas
    Kashuba, Elena V.
    Wahren, Britta
    Karpov, Vadim
    Isaguliants, Maria
    VACCINE, 2006, 24 (21) : 4541 - 4547
  • [10] Anti-HIV antibody and drug combinations exhibit synergistic activity against drug-resistant HIV-1 strains
    Qi, Qianqian
    Wang, Qian
    Chen, Weizao
    Yu, Fei
    Du, Lanying
    Dimitrov, Dimiter S.
    Lu, Lu
    Jiang, Shibo
    JOURNAL OF INFECTION, 2017, 75 (01) : 68 - 71
12345