Antiplasmodial Activity and Cytotoxicity of Plants Used in Traditional Medicine of Iran for the Treatment of Fever

被引:0
|
作者
Esmaeili, Somayeh [2 ,3 ]
Ghiaee, Azadeh [2 ,3 ]
Naghibi, Farzaneh [1 ,2 ,3 ]
Mosaddegh, Mahmoud [1 ,2 ,3 ]
机构
[1] Shahid Beheshti Univ Med Sci, Sch Pharm, Dept Pharmacognosy, Tehran, Iran
[2] Shahid Beheshti Univ Med Sci, Tradit Med & Mat Med Res Ctr TMRC, Tehran, Iran
[3] Shahid Beheshti Univ Med Sci, Sch Tradit Med, Dept Tradit Pharm, Tehran, Iran
关键词
Rosa damascena; Antiplasmodial; Malaria; Fever; Traditional medicine; ANTIMALARIAL ACTIVITY; EXTRACTS; MALARIA;
D O I
暂无
中图分类号
R9 [药学];
学科分类号
1007 ;
摘要
Malaria is the most serious parasitic disease and one of the oldest recorded diseases in the world. Because of the resistance of malaria parasites to current drugs, it is necessary to discover new antiplasmodial drugs. Traditional medicine is one of the important sources of new antiplasmodial drugs. In this study, twenty methanolic extracts from different parts of sixteen medicinal plants used in traditional medicine of Iran for the treatment of "Nobeh fever" and/or fever were screened for in-vivo antiplasmodial activity against Plasmodium berghei and cytotoxic effect on Madin-Darby bovine kidney cells (MDBK). Eleven species (55%) were found to have antiplasmodial activity. Methanolic extract from Rosa damascena Mill. reduced parasitemia by 57.7% compared to untreated control mice at intra-peritoneal (i.p.) injection doses of 10 mg/Kg per day for 4 days. This is the first report that mentioned in-vivo antiplasmodial activity of Rosa damascena Mill.
引用
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页码:103 / 107
页数:5
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