Application of the combinatorial chemistry to research of the natural products

被引：0
|
作者：
Zhang, C [1 ]
Li, WZ [1 ]
Yun, LH [1 ]
机构：
[1] Acad Mil Med Sci, Inst Pharmacol & Toxicol, Beijing 100850, Peoples R China
来源：
PROGRESS IN CHEMISTRY | 2003年 / 15卷 / 03期
关键词：
combinatorial chemistry; natural products; compound libraries;
D O I：
暂无
中图分类号：
O6 [化学];
学科分类号：
0703 ;
摘要：
Natural products are one of the most important sources of the lead compounds in drug discovery. Combinatorial chemistry is now playing important role in the research of the natural products. In recent years, a number of molecular libraries have been designed and synthesized based on natural templates and they will provide a useful method for the development of the drug research based on the natural products.
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收藏
页码：194 / 203
页数：10
相关论文
共 35 条
  • [1] Modern methods to produce natural-product libraries
    Abel, U
    Koch, C
    Speitling, M
    Hansske, FG
    [J]. CURRENT OPINION IN CHEMICAL BIOLOGY, 2002, 6 (04) : 453 - 458
  • [2] Solid-phase synthesis of macrolide analogues
    Akritopoulou-Zanze, I
    Sowin, TJ
    [J]. JOURNAL OF COMBINATORIAL CHEMISTRY, 2001, 3 (03): : 301 - 311
  • [3] The synthesis and evaluation of a solution phase indexed combinatorial library of non-natural polyenes for reversal of p-glycoprotein mediated multidrug resistance
    Andrus, MB
    Turner, TM
    Sauna, ZE
    Ambudkar, SV
    [J]. JOURNAL OF ORGANIC CHEMISTRY, 2000, 65 (16): : 4973 - 4983
  • [4] A method for the rapid synthesis of benzopyrone libraries employing a resin capture strategy
    Bhat, AS
    Whetstone, JL
    Brueggemeier, RW
    [J]. JOURNAL OF COMBINATORIAL CHEMISTRY, 2000, 2 (06): : 597 - 599
  • [5] A novel diterpenoid lactone-based scaffold for the generation of combinatorial libraries
    Biabani, MAF
    Grover, RK
    Singh, SK
    Kumar, S
    Raj, K
    Roy, R
    Kundu, B
    [J]. TETRAHEDRON LETTERS, 2001, 42 (40) : 7119 - 7121
  • [6] Total synthesis of distamycin A and 2640 analogues: A solution-phase combinatorial approach to the discovery of new, bioactive DNA binding agents and development of a rapid, high-throughput screen for determining relative DNA binding affinity or DNA binding sequence selectivity
    Boger, DL
    Fink, BE
    Hedrick, MP
    [J]. JOURNAL OF THE AMERICAN CHEMICAL SOCIETY, 2000, 122 (27) : 6382 - 6394
  • [7] Brohm D, 2002, ANGEW CHEM INT EDIT, V41, P307, DOI 10.1002/1521-3773(20020118)41:2<307::AID-ANIE307>3.0.CO
  • [8] 2-1
  • [9] The synthesis and biological characterization of a ceramide library
    Chang, YT
    Choi, J
    Ding, S
    Prieschl, EE
    Baumruker, T
    Lee, JM
    Chung, SK
    Schultz, PG
    [J]. JOURNAL OF THE AMERICAN CHEMICAL SOCIETY, 2002, 124 (09) : 1856 - 1857
  • [10] Natural products in drug discovery and development
    Cragg, GM
    Newman, DJ
    Snader, KM
    [J]. JOURNAL OF NATURAL PRODUCTS, 1997, 60 (01): : 52 - 60
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