DEVELOPMENT OF NEW SULFUR-CONTAINING CONJUGATED COMPOUNDS AS ANTI-HCV AGENTS

被引：7

作者：

Hwu, Jih Ru ^{[1
,2
]}

Lin, Shu-Yu ^{[1
]}

Tsay, Shwu-Chen ^{[1
]}

Singha, Raghunath ^{[1
]}

Pal, Benoy K. ^{[1
]}

Leyssen, Pieter ^{[3
]}

Neyts, Johan ^{[3
]}

机构：

[1] Natl Tsing Hua Univ, Dept Chem, Hsinchu 30013, Taiwan

[2] Natl Cent Univ, Dept Chem, Jhongli, Taiwan

[3] Katholieke Univ Leuven, Rega Inst Med Res, Louvain, Belgium

来源：

PHOSPHORUS SULFUR AND SILICON AND THE RELATED ELEMENTS | 2011年 / 186卷 / 05期

关键词：

Coumarin; guanosine; heterocycles; methylenethio linker; DERIVATIVES; INHIBITORS; POTENT; REPLICATION; GUANOSINE;

D O I：

10.1080/10426507.2010.520284

中图分类号：

O61 [无机化学];

学科分类号：

070301 ; 081704 ;

摘要：

Various conjugated compounds containing a coumarin moiety and a heterocyclic nucleus were synthesized. Their activity against hepatitis C virus was tested on subgenomic replicon replication in Huh 5-2 cells. Some heterobicycle-coumarin conjugates with the -S-CH2-linker were found to possess appealing antiviral activities. The sulfur atom in these conjugated compounds was found to be an essential element to their antiviral activity.

引用

页码：1144 / 1152

页数：9

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