Thymic tumours: a single center surgical experience and literature review on the current diagnosis and management of thymic malignancies

被引:1
|
作者
Minervini, Fabrizio [1 ]
Boschetti, Laura [2 ]
Gregor, Michael [2 ]
Provencio, Mariano [3 ]
Calvo, Virginia [3 ]
Kestenholz, Peter B. [1 ]
Lampridis, Savvas [4 ]
Patrini, Davide [5 ]
Bertoglio, Pietro [6 ]
Azenha, L. Filipe [1 ]
Sergi, Consolato M. [7 ]
Kocher, Gregor J. [8 ]
机构
[1] Cantonal Hosp Lucerne, Dept Thorac Surg, Luzern, Switzerland
[2] Cantonal Hosp Lucerne, Dept Hematol, Luzern, Switzerland
[3] Hosp Univ Puerta de Hierro Majadahonda, Dept Med Oncol, Madrid, Spain
[4] 424 Gen Mil Hosp, Dept Thorac Surg, Thessalonild, Greece
[5] Univ Coll London Hosp, Dept Thorac Surg, London, England
[6] IRCSS Azienda Osped Univ, Div Thorac Surg, Bologna, Italy
[7] Univ Ottawa, Childrens Hosp Eastern Ontario, Div Anat Pathol, Ottawa, ON, Canada
[8] Univ Bern, Bern Univ Hosp, Div Thorac Surg, Bern, Switzerland
关键词
Thymoma; thymic tumors; thymic carcinoma; ASSISTED THORACOSCOPIC SURGERY; FORTHCOMING 8TH EDITION; MYASTHENIA-GRAVIS; PHASE-II; TRANSCERVICAL THYMECTOMY; EPITHELIAL TUMORS; STAGING PROJECT; TNM CLASSIFICATION; PROGNOSTIC-FACTORS; INVASIVE THYMOMA;
D O I
10.21037/gs-21-517
中图分类号
R61 [外科手术学];
学科分类号
摘要
Objective: This study aimed to provide an extensive overview of clinical and pathological findings along with various therapeutic options analyzing in addiction, retrospectively, the surgical outcomes of a single center cohort. Background: Thymic neoplasms are rare thoracic tumors which commonly are located in the anterior mediastinum and are associated with a wide spectrum of clinical presentations. They may run an indolent course or could present a very aggressive biologic progression with infiltration of mediastinal structures and presence of distant metastases. The pathogenesis of these tumors is so far not completely clear. Several treatment modalities in a multidisciplinary setting have to be considered in order to provide the best treatment for patients affected by thymic tumors. Methods: We conducted a retrospective cohort analysis of all patients who underwent surgery due to thymic tumor in a university hospital located in Switzerland (Bern University Hospital) and then we performed a narrative review of the English literature using PubMed, Embase, Cochrane Database of Systematic Reviews and Scopus. Conclusions: Minimally invasive techniques play an important role in the treatment of thymic tumors. A careful patients selection in a multidisciplinary setting is mandatory in order to offer the best treatment for patients affected by thymic tumors.
引用
收藏
页码:3128 / 3140
页数:13
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