Analysis of ERCC1 and ERCC2 gene variants in osteosarcoma, colorectal and breast cancer

被引：13

作者：

Gomez-Diaz, Benjamin ^{[1
]}

de la Luz Ayala-Madrigal, Maria ^{[2
]}

Gutierrez-Angulo, Melva ^{[3
]}

Erazo Valle-Solis, Aura ^{[4
]}

Miguel Linares-Gonzalez, Luis ^{[1
]}

Gonzalez-Guzman, Roberto ^{[1
]}

Cruz-Guillen, David ^{[1
]}

Lilia Cedeno-Garciduenas, Ana ^{[1
]}

Canto, Patricia ^{[5
]}

Berenice Lopez-Hernandez, Luz ^{[4
]}

机构：

[1] Natl Inst Rehabil, Mexico City 14389, DF, Mexico

[2] Univ Guadalajara, Inst Human Genet, UCHS, Guadalajara 44430, Jalisco, Mexico

[3] Univ Guadalajara, Dept Clin, UCALTOS, Tepatitlan, Jalisco, Mexico

[4] Natl Med Ctr 20th November, Inst Social Secur State Workers, Mexico City, DF, Mexico

[5] Univ Nacl Autonoma Mexico, Fac Med, Obes Res Unit, Mexico City 04510, DF, Mexico

来源：

ONCOLOGY LETTERS | 2015年 / 9卷 / 04期

关键词：

ERCC1; ERCC2; cancer; Mexican-mestizos; DNA-REPAIR GENES; NUCLEOTIDE EXCISION-REPAIR; CHINESE POPULATION; HUMAN BLOOD; CELL-LINES; POLYMORPHISMS; RISK; SUSCEPTIBILITY; ASSOCIATIONS; ASP312ASN;

D O I：

10.3892/ol.2015.2894

中图分类号：

R73 [肿瘤学];

学科分类号：

100214 ;

摘要：

The Asn118Asn (rs11615) variant in the ERCC1 gene, and the Lys751Gln (rs13181) and Asp312Asn (rs1799793) variants in the ERCC2 gene have been associated with the development of varied types of cancer. The aim of the present study was to test for any association between the ERCC1 and ERCC2 gene variants and three different types of cancer in Mexican-mestizo patients. Patients and their respective controls were formed into three groups: The osteosarcoma group, with 28 patients and 97 controls; the colorectal group, with 108 patients and 119 controls; and the breast cancer group, with 71 patients and 74 controls. Genotyping was performed using TaqMan probes and quantitative polymerase chain reaction. Allele and genotype frequencies were compared using a (2) test. Only one SNP (rs1799793) was found to be associated with breast cancer. This is the first study analyzing the SNPs in ERCC1 and ERCC2 genes and the susceptibility to cancer in Mexican-mestizo patients with osteosarcoma, and colorectal and breast cancer.

引用

页码：1657 / 1661

页数：5

共 50 条

[1] ERCC1 and ERCC2 Variants Predict Survival in Gastric Cancer Patients
Li, Yangkai
Liu, Zhensheng
Liu, Hongliang
Wang, Li-E
Tan, Dongfeng
Ajani, Jaffer A.
Wei, Qing-Yi
[J]. PLOS ONE, 2013, 8 (09):
[2] Association of ERCC1 and ERCC2 polymorphisms with colorectal cancer risk in a Chinese population
Min Ni
Wei-zhong Zhang
Jin-rong Qiu
Fei Liu
Min Li
Ya-jie Zhang
Qing Liu
Jin Bai
[J]. Scientific Reports, 4
[3] Investigation of ERCC1 and ERCC2 gene polymorphisms and response to chemotherapy and overall survival in osteosarcoma
Zhang, Q.
Lv, L. Y.
Li, B. J.
Zhang, J.
Wei, F.
[J]. GENETICS AND MOLECULAR RESEARCH, 2015, 14 (03) : 11235 - 11241
[4] Association of ERCC1 and ERCC2 polymorphisms with colorectal cancer risk in a Chinese population
Ni, Min
Zhang, Wei-zhong
Qiu, Jin-rong
Liu, Fei
Li, Min
Zhang, Ya-jie
Liu, Qing
Bai, Jin
[J]. SCIENTIFIC REPORTS, 2014, 4
[5] The effect of ERCC1 and ERCC2 gene polymorphysims on response to cisplatin based therapy in osteosarcoma patients
Obiedat, Hadeel
Alrabadi, Nasr
Sultan, Eyad
Al Shatti, Marwa
Zihlif, Malek
[J]. BMC MEDICAL GENETICS, 2018, 19
[6] Association between ERCC1 and ERCC2 gene polymorphisms and susceptibility to pancreatic cancer
He, M. G.
Zheng, K.
Tan, D.
Wang, Z. X.
[J]. GENETICS AND MOLECULAR RESEARCH, 2016, 15 (01): : 1 - 7
[7] Association between ERCC1 and ERCC2 gene polymorphisms and chemotherapy response and overall survival in osteosarcoma
Cao, Z. H.
Yin, H. P.
Jiang, N.
Yu, B.
[J]. GENETICS AND MOLECULAR RESEARCH, 2015, 14 (03) : 10145 - 10151
[8] ERCC1 and ERCC2 polyrnorphisms and adult glioma
Wrensch, M
Kelsey, KT
Liu, M
Miike, R
Moghadassi, M
Sison, JD
Aldape, K
McMillan, A
Wiemels, J
Wiencke, JK
[J]. NEURO-ONCOLOGY, 2005, 7 (04) : 495 - 507
[9] Association of ERCC1 and ERCC2 Gene Polymorphisms with Pancreatic Cancer Risk: A Meta-Analysis
Xie, Fuyi
Sun, Qi
Zhang, En
Mu, Yinyu
[J]. CRITICAL REVIEWS IN EUKARYOTIC GENE EXPRESSION, 2020, 30 (03): : 231 - 237
[10] Association between ERCC1 and ERCC2 polymorphisms and breast cancer risk in a Chinese population
Zhao, R.
Ying, M. F.
[J]. GENETICS AND MOLECULAR RESEARCH, 2016, 15 (01):

← 1 2 3 4 5 →