IL-15 Is Overexpressed in γδ T Cells and Correlates with Disease Severity in Relapsing-Remitting Multiple Sclerosis

被引：3

作者：

Zarobkiewicz, Michal K. ^{[1
]}

Kowalska, Wioleta ^{[1
]}

Morawska, Izabela ^{[1
]}

Halczuk, Pawel ^{[2
,3
]}

Rejdak, Konrad ^{[2
]}

Bojarska-Junak, Agnieszka ^{[1
]}

机构：

[1] Med Univ Lublin, Dept Clin Immunol, PL-20093 Lublin, Poland

[2] Med Univ Lublin, Dept Neurol, PL-20090 Lublin, Poland

[3] Med Univ Lublin, Dept Histol & Embryol, Expt Cytol Unit, PL-20080 Lublin, Poland

来源：

JOURNAL OF CLINICAL MEDICINE | 2021年 / 10卷 / 18期

关键词：

IL-15; gamma delta T cells; multiple sclerosis; MS; EXPERIMENTAL AUTOIMMUNE ENCEPHALOMYELITIS; MESSENGER-RNA; INTERLEUKIN-15; LYMPHOCYTES; EXPRESSION;

D O I：

10.3390/jcm10184174

中图分类号：

R5 [内科学];

学科分类号：

1002 ; 100201 ;

摘要：

Interleukin 15 (IL-15) is known to be involved in the pathogenesis of multiple sclerosis (MS). An animal study revealed a distinct subset of IL-15-producing gamma delta T cells that correlate with disease severity. The aim of the current study was to test whether such a subset is also present in humans and its importance for the pathogenesis of MS. The peripheral blood from 29 patients with relapsing-remitting MS (including 6 relapses) and 22 controls was stained with monoclonal antibodies and analyzed with flow cytometry. The existence of IL-15+ gamma delta T cells was confirmed. Moreover, the percentage of IL-15+ gamma delta T is significantly increased in MS patients and correlates with disease severity. Nevertheless, additional functional studies are needed to fully understand the importance of those cells in multiple sclerosis pathogenesis

引用

页数：10

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