Innate immunity and urinary tract infection

被引:28
|
作者
Ching, Christina [1 ,2 ,3 ]
Schwartz, Laura [1 ,2 ]
Spencer, John David [1 ,2 ,4 ]
Becknell, Brian [1 ,2 ,4 ]
机构
[1] Nationwide Childrens Hosp, Nephrol & Urol Res Affin Grp, Columbus, OH 43205 USA
[2] Nationwide Childrens Hosp, Ctr Clin & Translat Res, Res Inst, Columbus, OH 43205 USA
[3] Nationwide Childrens Hosp, Div Urol, Columbus, OH USA
[4] Nationwide Childrens Hosp, Div Pediat Nephrol, 700 Childrens Dr, Columbus, OH 43205 USA
关键词
Urinary tract infection; Innate immunity; Pyelonephritis; Pattern recognition receptors; Cytokines; Antimicrobial peptides; UROPATHOGENIC E.-COLI; ESCHERICHIA-COLI; ANTIMICROBIAL PEPTIDES; NEUTROPHIL MIGRATION; ACUTE PYELONEPHRITIS; BACTERIAL CLEARANCE; CYTOKINE RESPONSES; KNOCKOUT MICE; CELLS; BLADDER;
D O I
10.1007/s00467-019-04269-9
中图分类号
R72 [儿科学];
学科分类号
100202 ;
摘要
Urinary tract infections are a severe public health problem. The emergence and spread of antimicrobial resistance among uropathogens threaten to further compromise the quality of life and health of people who develop acute and recurrent upper and lower urinary tract infections. The host defense mechanisms that prevent invasive bacterial infection are not entirely delineated. However, recent evidence suggests that versatile innate immune defenses play a key role in shielding the urinary tract from invading uropathogens. Over the last decade, considerable advances have been made in defining the innate mechanisms that maintain immune homeostasis in the kidney and urinary tract. When these innate defenses are compromised or dysregulated, pathogen susceptibility increases. The objective of this review is to provide an overview of how basic science discoveries are elucidating essential innate host defenses in the kidney and urinary tract. In doing so, we highlight how these findings may ultimately translate into the clinic as new biomarkers or therapies for urinary tract infection.
引用
收藏
页码:1183 / 1192
页数:10
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