Synthesis and reactivity of N-hydroxy-2-aminoindoles

被引：28

作者：

Belley, M ^{[1
]}

Sauer, E ^{[1
]}

Beaudoin, D ^{[1
]}

Duspara, P ^{[1
]}

Trimble, LA ^{[1
]}

Dubé, P ^{[1
]}

机构：

[1] Merck Frosst Ctr Therapeut Res, Pointe Claire, PQ H9R 4P8, Canada

来源：

TETRAHEDRON LETTERS | 2006年 / 47卷 / 02期

基金：

加拿大自然科学与工程研究理事会;

关键词：

reductive cyclization; N-hydroxy-2-aminoindole; catalytic hydrogenation; tetrakis(triphenylphosphine)palladium(0); (Ph3P)(4)Pd;

D O I：

10.1016/j.tetlet.2005.10.165

中图分类号：

O62 [有机化学];

学科分类号：

070303 ; 081704 ;

摘要：

Catalytic hydrogenation of (2-nitrophenyl)acetonitriles bearing an electron-withdrawing substituent alpha to the nitrile, using Pd/C and (Ph3P)(4)Pd, affords N-hydroxy-2-aminoindoles in good to excellent yields. (Ph3P)4Pd decreases the reduction rate of the intermediate hydroxylamine and acts as a catalyst during the cyclization onto the nitrile. (c) 2005 Elsevier Ltd. All rights reserved.

引用

页码：159 / 162

页数：4

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