Imaging of the mind involves an understanding of the brain and imaging technology. Much progress has been made over the past 400 years in defining the mind and developing tools for its investigation. However, its definition remains elusive and is perhaps one of the greatest scientific challenges. Scientific imaging has dramatically increased in power over the past 2 decades and is now a critical tool for studying the brain, the physical seat of the mind. Whether the mind can be imaged remains to be seen.