Pharmacological Therapeutics: Current Trends for Metabolic Dysfunction-Associated Fatty Liver Disease (MAFLD)

被引：13
|
作者：
Prasoppokakorn, Thaninee [1 ,2 ]
Pitisuttithum, Panyavee [2 ,3 ]
Treeprasertsuk, Sombat [1 ,2 ]
机构：
[1] Chulalongkorn Univ, Fac Med, Dept Med, Div Gastroenterol, 1873 Rama 4 Rd, Bangkok 10330, Thailand
[2] Thai Red Cross Soc, King Chulalongkorn Mem Hosp, 1873 Rama 4 Rd, Bangkok 10330, Thailand
[3] Chulalongkorn Univ, Div Gen Internal Med, Dept Med, Fac Med, Bangkok, Thailand
来源：
JOURNAL OF CLINICAL AND TRANSLATIONAL HEPATOLOGY | 2021年 / 9卷 / 06期
关键词：
Metabolic dysfunction-associated fatty liver disease; Nonalcoholic fatty liver disease; Nonalcoholic steatohepatitis; Pharmacological treatment; PLACEBO-CONTROLLED TRIAL; PROLIFERATOR-ACTIVATED RECEPTOR; NONALCOHOLIC STEATOHEPATITIS; VITAMIN-E; OBETICHOLIC ACID; PIOGLITAZONE; FIBROSIS; METAANALYSIS; MULTICENTER; AGONISTS;
D O I：
10.14218/JCTH.2021.00189
中图分类号：
R57 [消化系及腹部疾病];
学科分类号：
摘要：
Metabolic dysfunction-associated fatty liver disease (MAFLD) is a new term from nonalcoholic fatty liver disease (NAFLD) and is a positive diagnosis based on histopathology, imaging, or blood biomarkers. MAFLD is one of the common causes of liver dysfunction worldwide, likely due to the increase in metabolic syndrome as well as the high burden of disease and its relationship to other extrahepatic conditions. However, effective pharmacological therapeutic agents are still lacking; current management largely focuses on weight reduction and lifestyle modification. The purpose of this review was to summarize the updated evidence of novel therapies targeting different pathogenetic pathways in MAFLD.
引用
收藏
页码：939 / 946
页数：8
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