Current status of biomarker research in neurology

被引：27

作者：

Polivka, Jiri ^{[1
,2
]}

Polivka, Jiri, Jr. ^{[3
,4
]}

Krakorova, Kristyna ^{[1
,2
]}

Peterka, Marek ^{[1
,2
]}

Topolcan, Ondrej ^{[5
]}

机构：

[1] Charles Univ Prague, Fac Med Plzen, Dept Neurol, Husova 3, Plzen 30166, Czech Republic

[2] Fac Hosp Plzen, Dept Neurol, E Benese 13, Plzen 30599, Czech Republic

[3] Charles Univ Prague, Dept Histol & Embryol, Husova 3, Plzen 30166, Czech Republic

[4] Charles Univ Prague, Fac Med Plzen, Biomed Ctr, Husova 3, Plzen 30166, Czech Republic

[5] Fac Hosp Plzen, Cent Imunoanalyt Lab, E Benese 13, Plzen 30599, Czech Republic

来源：

EPMA JOURNAL | 2016年 / 7卷

关键词：

Biomarker; Personalized medicine; Neuro-oncology; Stroke; Alzheimer's disease; Parkinson's disease; Multiple sclerosis; Predictive preventive personalized medicine; MILD COGNITIVE IMPAIRMENT; AMYLOID PRECURSOR PROTEIN; MAGNIMS CONSENSUS GUIDELINES; INTEGRATED GENOMIC ANALYSIS; PHASE-III TRIAL; ALZHEIMERS-DISEASE; MULTIPLE-SCLEROSIS; PARKINSONS-DISEASE; INTERFERON-BETA; ANAPLASTIC OLIGODENDROGLIOMA;

D O I：

10.1186/s13167-016-0063-5

中图分类号：

R5 [内科学];

学科分类号：

1002 ; 100201 ;

摘要：

Neurology is one of the typical disciplines where personalized medicine has been recently becoming an important part of clinical practice. In this article, the brief overview and a number of examples of the use of biomarkers and personalized medicine in neurology are described. The various issues in neurology are described in relation to the personalized medicine and diagnostic, prognostic as well as predictive blood and cerebrospinal fluid biomarkers. Such neurological domains discussed in this work are neuro-oncology and primary brain tumors glioblastoma and oligodendroglioma, cerebrovascular diseases focusing on stroke, neurodegenerative disorders especially Alzheimer's and Parkinson's diseases and demyelinating diseases such as multiple sclerosis. Actual state of the art and future perspectives in diagnostics and personalized treatment in diverse domains of neurology are given.

引用

页数：13

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