Progressive multifocal leukoencephalopathy in a patient with primary amyloid light-chain amyloidosis

被引：0

作者：

Katsuse, Kazuto ^{[1
]}

Akiyama, Kaho ^{[1
]}

Ishida, Tadao ^{[2
]}

Kitayama, Chigusa ^{[3
]}

Ishibashi, Yoshitaka ^{[3
]}

Ochi, Mieko ^{[4
]}

Kumasaka, Toshio ^{[4
]}

Takahashi, Kenta ^{[5
]}

Suzuki, Tadaki ^{[5
]}

Nakamichi, Kazuo ^{[6
]}

Saijo, Masayuki ^{[6
]}

Hashida, Hideji ^{[1
]}

机构：

[1] Japanese Red Cross Med Ctr, Dept Neurol, Shibuya Ku, 4-1-22 Hiroo, Tokyo 1508935, Japan

[2] Japanese Red Cross Med Ctr, Dept Hematol, Shibuya Ku, 4-1-22 Hiroo, Tokyo 1508935, Japan

[3] Japanese Red Cross Med Ctr, Dept Nephrol, Shibuya Ku, 4-1-22 Hiroo, Tokyo 1508935, Japan

[4] Japanese Red Cross Med Ctr, Dept Pathol, Shibuya Ku, 4-1-22 Hiroo, Tokyo 1508935, Japan

[5] Natl Inst Infect Dis, Dept Pathol, Shinjuku Ku, 1-23-1 Toyama, Tokyo 1628640, Japan

[6] Natl Inst Infect Dis, Dept Virol 1, Shinjuku Ku, 1-23-1 Toyama, Tokyo 1628640, Japan

来源：

CLINICAL NEUROLOGY AND NEUROSURGERY | 2020年 / 192卷

基金：

日本学术振兴会;

关键词：

Progressive multifocal leukoencephalopathy (PML); JC virus (JCV); Amyloid light-chain (AL) amyloidosis; End-stage renal disease; Immunosuppression;

D O I：

10.1016/j.clineuro.2020.105709

中图分类号：

R74 [神经病学与精神病学];

学科分类号：

摘要：

Progressive multifocal leukoencephalopathy (PML) is a neurological complication that affects immunocompromised patients. We describe the case of a 67-year-old man with amyloid light-chain (AL) amyloidosis who developed PML three years after undergoing autologous peripheral blood stem cell transplantation (auto-PBSCT). Although hematological remission was maintained with mild chemotherapy after auto-PBSCT, the patient experienced persistent lymphopenia and hypogammaglobulinemia. This report shows that PML can occur in immunodeficient patients with AL amyloidosis and highlights the need for clinicians to monitor the immunocompetence of such patients and watch for the emergence of neurological symptoms. © 2020 Elsevier B.V.

引用

页数：4

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