You Are What Your Dad Ate

被引:63
|
作者
Ferguson-Smith, Anne C. [1 ,2 ]
Patti, Mary-Elizabeth [3 ,4 ]
机构
[1] Univ Cambridge, Dept Physiol Dev & Neurosci, Cambridge CB2 3EG, England
[2] Singapore Inst Clin Sci, Brenner Ctr Mol Med, Singapore, Singapore
[3] Joslin Diabet Ctr, Div Res, Boston, MA 02215 USA
[4] Harvard Univ, Sch Med, Boston, MA 02215 USA
关键词
IN-UTERO; MAMMALS; DIET; RATS;
D O I
10.1016/j.cmet.2011.01.011
中图分类号
Q2 [细胞生物学];
学科分类号
071009 ; 090102 ;
摘要
Maternal nutrition and metabolism are critical determinants of adult offspring health. Recent reports describe adverse offspring outcomes associated with the father's diet, indicating nongenetic inheritance of paternal experience. Determining underlying mechanisms may require reconsideration of our understanding of the heritability of epigenetic states.
引用
收藏
页码:115 / 117
页数:3
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