[1] Sunnybrook Hlth Sci Ctr, Dept Crit Care Med, Toronto, ON M4N 3M5, Canada
[2] Univ Toronto, Interdept Div Crit Care Med, Toronto, ON, Canada
[3] Univ Toronto, Dept Med, Toronto, ON, Canada
[4] Columbia Univ, Dept Anesthesiol, New York, NY USA
[5] Columbia Univ, Dept Epidemiol, New York, NY USA