Improved detection limits using a hand-held optical imager with coregistration capabilities

被引：7
|
作者：
Erickson, Sarah J. [1 ]
Martinez, Sergio L. [1 ]
Gonzalez, Jean [1 ]
Caldera, Lizeth [1 ]
Godavarty, Anuradha [1 ]
机构：
[1] Florida Int Univ, Dept Biomed Engn, Miami, FL 33174 USA
来源：
BIOMEDICAL OPTICS EXPRESS | 2010年 / 1卷 / 01期
基金：
美国国家卫生研究院;
关键词：
D O I：
10.1364/BOE.1.000126
中图分类号：
Q5 [生物化学];
学科分类号：
071010 ; 081704 ;
摘要：
Optical imaging is emerging as a non-invasive and non-ionizing method for breast cancer diagnosis. A hand-held optical imager has been developed with coregistration facilities towards flexible imaging of different tissue volumes and curvatures in near real-time. Herein, fluorescence-enhanced optical imaging experiments are performed to demonstrate deeper target detection under perfect and imperfect (100:1) uptake conditions in (liquid) tissue phantoms and in vitro. Upon summation of multiple scans (fluorescence intensity images), fluorescent targets are detected at greater depths than from single scan alone. (C) 2010 Optical Society of America
引用
收藏
页码：126 / 134
页数：9
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