In Cell Interactome of Oleocanthal, an Extra Virgin Olive Oil Bioactive Component

被引：0

作者：

Cassiano, Chiara ^{[1
]}

Casapullo, Agostino ^{[1
]}

Tosco, Alessandra ^{[1
]}

Monti, Maria Chiara ^{[1
]}

Riccio, Raffaele ^{[1
]}

机构：

[1] Univ Salerno, Dept Pharm, I-84084 Salerno, Italy

来源：

NATURAL PRODUCT COMMUNICATIONS | 2015年 / 10卷 / 06期

关键词：

Chemical proteomics; Click-chemistry; Olive oil; Heat shock proteins; BIOLOGICAL-ACTIVITIES; PHENOLIC-COMPOUNDS; TAU-PROTEIN; FIBRILLIZATION; METABOLISM;

D O I：

暂无

中图分类号：

R914 [药物化学];

学科分类号：

100701 ;

摘要：

A copper-(I)-catalyzed variation of the Huisgen 1,3-dipolar cycloaddition has been applied to lead the in living-cell mass-spectrometry based identification of protein targets of oleocanthal, a natural metabolite daily ingested by millions of people. Chemical proteomics revealed heat-shock proteins, HSP70 and HSP90, as main oleocanthal interactors in living systems. These two proteins are involved in cancer development and, thus, our findings could have important outcomes for a deep evaluation of the bio-pharmacological significance of oleocanthal.

引用

页码：1013 / 1016

页数：4

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