Identification of potential long non-coding RNA biomarkers for breast cancer patients with somatic BRCA1 mutations from RNA-Seq datasets

被引：2
|
作者：
Cai, Jia-Hua [1 ]
Chen, Yu-Ching [1 ]
Chu, Hsueh-Ting [1 ,2 ]
Tsai, Jeffrey J. P. [1 ]
机构：
[1] Asia Univ, Dept Bioinformat & Med Engn, Taichung, Taiwan
[2] Asia Univ, Dept Comp Sci & Informat Engn, Taichung, Taiwan
来源：
PROCEEDINGS 2018 IEEE 18TH INTERNATIONAL CONFERENCE ON BIOINFORMATICS AND BIOENGINEERING (BIBE) | 2018年
关键词：
BRCA1; long non-coding RNAs; driver mutations;
D O I：
10.1109/BIBE.2018.00060
中图分类号：
R318 [生物医学工程];
学科分类号：
0831 ;
摘要：
The gene BRCA1 is a human tumor suppressor gene found in all humans, and it was reported that around 5-10% of people with breast cancer have a mutation of their BRCA1 genes. In this study, we investigated potential long non-coding RNA biomarkers for BRCA1 mutation carriers breast cancer cases. From differential expression analysis of RNA-Seq data, we identified 6 significant long non-coding genes (p-value < 0.05). There are three long non-coding genes which were reported as potential biomarkers in breast cancer: AC008268.1, AC091013.1 and AL021395.1. Then the other three genes (AC008592.5, AC090204.1, LINC02570) are novel candidates reported in this study.
引用
收藏
页码：273 / 276
页数：4
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