Toxic Effects in Zebrafish Embryos Following Exposure to PAM

被引：0

作者：

Cao, Xiuming ^{[1
]}

Xie, Jianing ^{[2
]}

Wan, Xiaofeng ^{[3
]}

机构：

[1] Harbin Univ Commerce, Ctr Life Sci & Environm Sci, Harbin 150076, Heilongjiang, Peoples R China

[2] Harbin Univ Commerce, Workstat Postdoctoral Sci Res, Drug Res Ctr, Harbin 150076, Heilongjiang, Peoples R China

[3] Minist Educ, Nat Antitumor Drug Engn Res Ctr, Harbin 150076, Heilongjiang, Peoples R China

来源：

CONFERENCE ON ENVIRONMENTAL POLLUTION AND PUBLIC HEALTH, VOL 1-2 | 2010年

关键词：

PAM; aquatic; zebrafish(Brachydanio rerio); toxic effect; SDH; LDH; MODEL;

D O I：

暂无

中图分类号：

X [环境科学、安全科学];

学科分类号：

08 ; 0830 ;

摘要：

In order to provide more information for aquatic risk about PAM,24 h,48h and 96 h acute toxicity of PAM to adult zebrafish (Brachydanio rerio) were tested,and the variance of LDH and SDH activity in zebrafish under sublethal concentrations was investigated.The results showed that PAM is low-toxic.24h,48h,96h LD50 for PAM were 452.47 mg . L-1, 411.70 mg . L-1 and 335.33 mg . L-1. In the case of LDH and SDH test,the induction of LDH and SDH activity was observed during the 40t-test,and inhibition effects observed.Moreover,induction effect on LDH and SDH was significant. In general,the results showed difference in acute toxicity to zebrafish and a pronounced difference in effects on LDH and SDH activity in zebrafish.

引用

页码：795 / +

页数：2

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