Introduction: The objective of this study is to evaluate the 102 most cited publications in the literature related to sepsis in terms of bibliometric properties. Material and Method: After obtaining the approval of the ethical committee for this descriptive cross-sectional study, the first 102 most cited relevant publications were determined using appropriate keywords in the "advanced mode" feature of the "Institute for Scientific Information Web of Science" search engine. The data were then entered into SPSS 24.0 software program. The One Way ANOVA test, Kruskal Wallis test and Mann Whitney U test were used for the comparison of the groups. Results: The literature analysis conducted in this study revealed a total of 123198 publications in the field of sepsis over the 1975 through 2021. The most cited article had 7072 citations, the least cited articles had 747 citations. 46% of the 102 most cited articles were published between 2000 and 2009, with a total citation average rate of 1620,46 +/- 1427,96 and an annual citation average rate of 120,42 +/- 145,55. 37,3% of these studies were sepsis treatment-related while 33,3% were related to sepsis pathogenesis. 86,3% of journals originated from the United States and 13,7% from the United Kingdom. The three journals that appeared most frequently in the top 102 were "The New England Journal of Medicine" (NEJM) (%19,6), "Critical Care Medicine" (%16,7) ve "The Journal of the American Medical Association" (JAMA) (%13,7). There was a significant relationship was found between the year of publication of the article, the journal in wich they were published, the type of syudy, subject area and the total number of citations per year; and between the type of study, subject area of the article and the total number of citations (p<0.05). Conclusion: The present article is the first study in the literature to evaluate the top 102 most cited studies related to serpsis. In our study, it is noteworthy that the articles published after 2015, the guidelines and the articles about the diagnosis of sepsis have more citations.