Cellular and Molecular Mechanisms of Inflammation-induced Angiogenesis

被引：177

作者：

Szade, Agata ^{[1
]}

Grochot-Przeczek, Anna ^{[1
]}

Florczyk, Urszula ^{[1
]}

Jozkowicz, Alicja ^{[1
]}

Dulak, Jozef ^{[1
,2
]}

机构：

[1] Jagiellonian Univ, Fac Biochem Biophys & Biotechnol, Dept Med Biotechnol, Krakow, Poland

[2] Jagiellonian Univ, Malopolska Ctr Biotechnol, Krakow, Poland

来源：

IUBMB LIFE | 2015年 / 67卷 / 03期

关键词：

hypoxia; NF-B; HIF; microRNA; heme oxygenase-1; Nrf2; tumor; HYPOXIA-INDUCIBLE FACTOR; ENDOTHELIAL GROWTH-FACTOR; TUMOR-NECROSIS-FACTOR; ISCHEMIA-INDUCED ANGIOGENESIS; MONOCYTE CHEMOTACTIC PROTEIN-1; MESENCHYMAL STEM-CELLS; BONE-MARROW-CELLS; FACTOR-I HIF-1; HEME OXYGENASE-1; NITRIC-OXIDE;

D O I：

10.1002/iub.1358

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

Blood vessel formation is a fundamental process for the development of organism and tissue regeneration. Of importance, angiogenesis occurring during postnatal development is usually connected with inflammation. Here, we review how molecular and cellular mechanisms underlying inflammatory reactions regulate angiogenesis. Inflamed tissues are characterized by hypoxic conditions and immune cell infiltration. In this review, we describe an interplay of hypoxia-inducible factors (HIFs), HIF1 and HIF2, as well as NF-B and nitric oxide in the regulation of angiogenesis. The mobilization of macrophages and the differential role of M1 and M2 macrophage subsets in angiogenesis are also discussed. Next, we present the current knowledge about microRNA regulation of inflammation in the context of new blood vessel formation. Finally, we describe how the mechanisms involved in inflammation influence tumor angiogenesis. We underlay and discuss the role of NF-E2-related factor 2/heme oxygenase-1 pathway as crucial in the regulation of inflammation-induced angiogenesis. (c) 2015 IUBMB Life, 67(3):145-159, 2015

引用

页码：145 / 159

页数：15

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