Article Multi-omic analysis in injured humans: Patterns align with outcomes and treatment responses

被引：49

作者：

Wu, Junru ^{[1
,2
,3
,4
,5
]}

Vodovotz, Yoram ^{[1
,2
]}

Abdelhamid, Sultan ^{[1
,2
]}

Guyette, Francis X. ^{[6
]}

Yaffe, Michael B. ^{[7
,8
]}

Gruen, Danielle S. ^{[1
,2
]}

Cyr, Anthony ^{[1
,2
]}

Okonkwo, David O. ^{[9
]}

Kar, Upendra K. ^{[1
,2
]}

Krishnamoorthi, Neha ^{[1
]}

Voinchet, Robert G. ^{[1
]}

Billiar, Isabel M. ^{[1
]}

Yazer, Mark H. ^{[10
]}

Namas, Rami A. ^{[1
,2
]}

Daley, Brian J. ^{[11
]}

Miller, Richard S. ^{[12
]}

Harbrecht, Brian G. ^{[13
]}

Claridge, Jeffrey A. ^{[14
]}

Phelan, Herbert A. ^{[15
]}

Zuckerbraun, Brian S. ^{[1
,2
]}

Johansson, Par, I ^{[16
]}

Stensballe, Jakob ^{[16
,17
,18
,19
]}

Morrissey, James H. ^{[20
]}

Tracy, Russell P. ^{[21
,22
]}

Wisniewski, Stephen R. ^{[23
]}

Neal, Matthew D. ^{[1
,2
]}

Sperry, Jason L. ^{[1
,2
]}

Billiar, Timothy R. ^{[1
,2
]}

机构：

[1] Univ Pittsburgh, Dept Surg, Pittsburgh, PA 15260 USA

[2] Univ Pittsburgh, Pittsburgh Trauma Res Ctr, Pittsburgh, PA 15260 USA

[3] Cent South Univ, Xiangya Hosp 3, Dept Cardiol, Changsha, Peoples R China

[4] Cent South Univ, Xiangya Hosp 3, Ctr Pharmacol, Changsha, Peoples R China

[5] Cent South Univ, Xiangya Sch Med, Eight Year Program Med, Changsha, Peoples R China

[6] Univ Pittsburgh, Dept Emergency Med, Med, Pittsburgh, PA USA

[7] MIT, Koch Inst Integrat Canc Res, 77 Massachusetts Ave, Cambridge, MA 02139 USA

[8] Harvard Med Sch, Beth Israel Deaconess Med Ctr, Dept Surg, Boston, MA 02115 USA

[9] Univ Pittsburgh, Dept Neurol Surg, Pittsburgh, PA 15260 USA

[10] Inst Transfus Med, Pittsburgh, PA USA

[11] Univ Tennessee, Hlth Sci Ctr, Dept Surg, Knoxville, TN USA

[12] JPS Hlth Network, Dept Surg, Ft Worth, TX USA

[13] Univ Louisville, Dept Surg, Louisville, KY 40292 USA

[14] Case Western Reserve Univ, Metro Hlth Med Ctr, Cleveland, OH 44106 USA

[15] Univ Texas Southwestern, Dept Surg, Dallas, TX USA

[16] Copenhagen Univ Hosp, Rigshosp, Sect Transfus Med, Capital Reg Blood Bank, Copenhagen, Denmark

[17] Copenhagen Univ Hosp, Rigshosp, Ctr Head & Orthopaed, Dept Anesthesia, Copenhagen, Denmark

[18] Copenhagen Univ Hosp, Rigshosp, Ctr Head & Orthopaed, Trauma Ctr, Copenhagen, Denmark

[19] Capital Reg Denmark, Emergency Med Serv, Hillerod, Denmark

[20] Univ Michigan, Sch Med, Dept Biol Chem, Ann Arbor, MI 48109 USA

[21] Univ Vermont, Lamer Coll Med, Dept Pathol, Colchester, VT USA

[22] Univ Vermont, Lamer Coll Med, Lab Med & Biochem, Colchester, VT USA

[23] Univ Pittsburgh, Grad Sch Publ Hlth, Pittsburgh, PA USA

来源：

CELL REPORTS MEDICINE | 2021年 / 2卷 / 12期

基金：

美国国家卫生研究院;

关键词：

TRAUMA-INDUCED COAGULOPATHY; MOLECULAR-PATTERNS; COMPLEMENT; MORTALITY; PLASMA; RISK; INFLAMMATION; COAGULATION; MEDIATORS; IMMUNITY;

D O I：

10.1016/j.xcrm.2021.100478

中图分类号：

Q2 [细胞生物学];

学科分类号：

071009 ; 090102 ;

摘要：

Trauma is a leading cause of death and morbidity worldwide. Here, we present the analysis of a longitudinal multi-omic dataset comprising clinical, cytokine, endotheliopathy biomarker, lipidome, metabolome, and proteome data from severely injured humans. A "systemic storm"pattern with release of 1,061 markers, together with a pattern suggestive of the "massive consumption"of 892 constitutive circulating markers, is identified in the acute phase post-trauma. Data integration reveals two human injury response endotypes, which align with clinical trajectory. Prehospital thawed plasma rescues only endotype 2 patients with traumatic brain injury (30-day mortality: 30.3 versus 75.0%; p = 0.0015). Ubiquitin carboxy-terminal hydrolase L1 (UCHL1) was identified as the most predictive circulating biomarker to identify endotype 2-traumatic brain injury (TBI) patients. These response patterns refine the paradigm for human injury, while the datasets provide a resource for the study of critical illness, trauma, and human stress responses.

引用

页数：23

共 50 条

[1] Multi-Omic Profiling of Adiposity Distribution Patterns
Pan, Michael
Dron, Jacqueline
Schuermans, Art
Agrawal, Saaket
Fourman, Lindsay
Koyama, Satoshi
Hornsby, Whitney
Peloso, Gina
Natarajan, Pradeep
CIRCULATION, 2024, 150
[2] Signal metrics analysis of oscillatory patterns in bacterial multi-omic networks
Bardozzo, Francesco
Lio, Pietro
Tagliaferri, Roberto
BIOINFORMATICS, 2021, 37 (10) : 1411 - 1419
[3] Multi-omic data analysis using Galaxy
Boekel, Jorrit
Chilton, John M.
Cooke, Ira R.
Horvatovich, Peter L.
Jagtap, Pratik D.
Kall, Lukas
Lehtio, Janne
Lukasse, Pieter
Moerland, Perry D.
Griffin, Timothy J.
NATURE BIOTECHNOLOGY, 2015, 33 (02) : 137 - 139
[4] Multi-omic data analysis using Galaxy
Jorrit Boekel
John M Chilton
Ira R Cooke
Peter L Horvatovich
Pratik D Jagtap
Lukas Käll
Janne Lehtiö
Pieter Lukasse
Perry D Moerland
Timothy J Griffin
Nature Biotechnology, 2015, 33 : 137 - 139
[5] Origin of breath isoprene in humans is revealed via multi-omic investigations
Sukul, Pritam
Richter, Anna
Junghanss, Christian
Schubert, Jochen K.
Miekisch, Wolfram
COMMUNICATIONS BIOLOGY, 2023, 6 (01)
[6] Origin of breath isoprene in humans is revealed via multi-omic investigations
Pritam Sukul
Anna Richter
Christian Junghanss
Jochen K. Schubert
Wolfram Miekisch
Communications Biology, 6
[7] Multi-Omic Analysis of Mouse Renal Tubule Cell Responses Following Unilateral Nephrectomy
Kikuchi, Hiroaki
Knepper, Mark A.
JOURNAL OF THE AMERICAN SOCIETY OF NEPHROLOGY, 2021, 32 (10): : 759 - 759
[8] Multi-Omic Analysis: A Possible Platform Toward Personalized and Adaptable Cancer Treatment
Benesch, Matthew G. K.
Cherkassky, Leonid
Nurkin, Steven J.
ANNALS OF SURGICAL ONCOLOGY, 2024, 31 (08) : 4831 - 4833
[9] Multi-omic Analysis Enhances Prediction Of Infantile Wheezing
Beheshti, Ramin
Hicks, Steven
Frangos, Patrick
JOURNAL OF ALLERGY AND CLINICAL IMMUNOLOGY, 2023, 151 (02) : AB210 - AB210
[10] Identification of inflammatory dendritic cells by a multi-omic analysis
Dutertre, Charles-Antoine
Ginhoux, Florent
M S-MEDECINE SCIENCES, 2020, 36 (11): : 976 - 979

← 1 2 3 4 5 →