The Ocular Surface Glycocalyx and its Alteration in Dry Eye Disease: A Review

被引：37
|
作者：
Uchino, Yuichi [1 ]
机构：
[1] Keio Univ, Sch Med, Dept Ophthalmol, Tokyo, Japan
来源：
INVESTIGATIVE OPHTHALMOLOGY & VISUAL SCIENCE | 2018年 / 59卷 / 14期
关键词：
glycocalyx barrier; transmembrane mucins; MUC1; MUC4; MUC16; galectin-3; diquafosol; rebamipide; GOBLET CELL-DENSITY; HUMAN CORNEAL; CONJUNCTIVAL EPITHELIA; SODIUM HYALURONATE; SJOGRENS-SYNDROME; MUCIN EXPRESSION; GENE-EXPRESSION; GALECTIN-3; REBAMIPIDE; MUC16;
D O I：
10.1167/iovs.17-23756
中图分类号：
R77 [眼科学];
学科分类号：
100212 ;
摘要：
Many studies have revealed that transmembrane mucins, large glycoproteins with heavily glycosylated glycans, are essential for maintaining ocular surface epithelium lubrication and wettability. Recent reports indicate that transmembrane mucins and galectin-3, a chimera type of galectin that binds beta-galactoside in the glycan, play a crucial role in maintaining the epithelial glycocalyx barrier. This review summarizes current evidence regarding the role of galectin-3, the role of the three major transmembrane mucins (i.e., MUC1, MUC4, and MUC16), in the maintenance of ocular surface wettability and transcellular barrier. Pathological mechanisms of glycocalyx barrier disruption and epithelial surface wettability decreases in dry eye disease are also summarized. Lastly, new ophthalmic drugs that target transmembrane mucin are described.
引用
收藏
页码：DES157 / DES162
页数：6
相关论文
共 50 条
  • [1] Dry eye and ocular surface disease
    Yiu, Samuel C.
    [J]. SAUDI JOURNAL OF OPHTHALMOLOGY, 2014, 28 (03) : 163 - 163
  • [2] Ocular Surface and Dry Eye in Graves' Disease
    Gurdal, Canan
    Sarac, Ozge
    Genc, Ipek
    Kirimlioglu, Hale
    Takmaz, Tamer
    Can, Izzet
    [J]. CURRENT EYE RESEARCH, 2011, 36 (01) : 8 - 13
  • [3] Review: MicroRNAs in ocular surface and dry eye diseases
    Rassi, Diane Meyre
    De Paiva, Cintia S.
    Dias, Lara Cristina
    Modulo, Carolina Maria
    Adriano, Leidiane
    Fantucci, Marina Zilio
    Rocha, Eduardo Melani
    [J]. OCULAR SURFACE, 2017, 15 (04): : 660 - 669
  • [4] Ocular Surface Ion Transport and Dry Eye Disease
    Lindgren, Ethan S.
    Cil, Onur
    Verkman, Alan S.
    Pasricha, Neel D.
    [J]. CURRENT OPHTHALMOLOGY REPORTS, 2022, 10 (04) : 188 - 197
  • [5] RELATIONSHIP OF THE DRY EYE TO PRIMARY OCULAR SURFACE DISEASE
    THOFT, RA
    [J]. TRANSACTIONS OF THE OPHTHALMOLOGICAL SOCIETIES OF THE UNITED KINGDOM, 1985, 104 : 452 - 457
  • [6] Ocular Surface Ion Transport and Dry Eye Disease
    Ethan S. Lindgren
    Onur Cil
    Alan S. Verkman
    Neel D. Pasricha
    [J]. Current Ophthalmology Reports, 2022, 10 : 188 - 197
  • [7] The Human Ocular Surface Microbiome and Its Associations with the Tear Proteome in Dry Eye Disease
    Schlegel, Irina
    De Gouyon Matignon de Pontourade, Claire M. F.
    Lincke, Joel-Benjamin
    Keller, Irene
    Zinkernagel, Martin S.
    Zysset-Burri, Denise C.
    [J]. INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES, 2023, 24 (18)
  • [8] Dry eye disease and ocular surface characteristics in patients with keratoconus
    Mirza, Enver
    Oltulu, Refik
    Oltulu, Pembe
    Mirza, Gunsu D.
    Okka, Mehmet
    [J]. SAUDI JOURNAL OF OPHTHALMOLOGY, 2022, 36 (01) : 117 - 121
  • [9] Ocular surface disease index for the diagnosis of dry eye syndrome
    Oezcura, Fatih
    Aydin, Sayime
    Helvaci, Mehmet Rami
    [J]. OCULAR IMMUNOLOGY AND INFLAMMATION, 2007, 15 (05) : 389 - 393
  • [10] The ocular surface and tear film and their dysfunction in dry eye disease
    Rolando, M
    Zierhut, M
    [J]. SURVEY OF OPHTHALMOLOGY, 2001, 45 : S203 - S210
12345