Biomembrane signal transduction and apoptosis

被引:0
|
作者
Xin, H [1 ]
Yan, GT [1 ]
Chen, BZ [1 ]
机构
[1] PLA Gen Hosp, Biochem Lab, Beijing 100853, Peoples R China
关键词
apoptosis; caspase; bcl-2; gene; mitochondria;
D O I
暂无
中图分类号
Q5 [生物化学]; Q7 [分子生物学];
学科分类号
071010 ; 081704 ;
摘要
A variety of extra-cellular signals could activate the target molecules and induce the associated biological effects depended on different signal pathways. Apoptosis, or programmed cell death, is a conservation process essential for normal development and homeostasis of biologist. it's known that a number of factors and pathways can lead to apoptosis. Specific phosphorlipids and proteins of biomembrane could activate the signal cascades of apoptosis. The interaction of caspases, bcl-2 family and mitochondria play an essential role in regulation of apoptosis.
引用
收藏
页码:52 / 55
页数:4
相关论文
共 15 条
  • [1] Apoptosis control by death and decoy receptors
    Ashkenazi, A
    Dixit, VM
    [J]. CURRENT OPINION IN CELL BIOLOGY, 1999, 11 (02) : 255 - 260
  • [2] Regulatory mechanisms of transmembrane phospholipid distributions and pathophysiological implications of transbilayer lipid scrambling
    Bevers, EM
    Comfurius, P
    Dekkers, DWC
    Harmsma, M
    Zwaal, RFA
    [J]. LUPUS, 1998, 7 : S126 - S131
  • [3] FADD, A NOVEL DEATH DOMAIN-CONTAINING PROTEIN, INTERACTS WITH THE DEATH DOMAIN OF FAS AND INITIATES APOPTOSIS
    CHINNAIYAN, AM
    OROURKE, K
    TEWARI, M
    DIXIT, VM
    [J]. CELL, 1995, 81 (04) : 505 - 512
  • [4] DAVID W, 1997, FEBS LETT, V410, P96
  • [5] HUQ R, 1998, CANC METASTASIS REV, V17, P233
  • [6] ITOH N, 1993, J IMMUNOL, V151, P621
  • [7] JIANGUO Z, 1998, TOXICOL LETT, V102, P121
  • [8] The release of cytochrome c from mitochondria: A primary site for Bcl-2 regulation of apoptosis
    Kluck, RM
    BossyWetzel, E
    Green, DR
    Newmeyer, DD
    [J]. SCIENCE, 1997, 275 (5303) : 1132 - 1136
  • [9] FLICE, a novel FADD-homologous ICE/CED-3-like protease, is recruited to the CD95 (Fas/APO-1) death-inducing signaling complex
    Muzio, M
    Chinnaiyan, AM
    Kischkel, FC
    ORourke, K
    Shevchenko, A
    Ni, J
    Scaffidi, C
    Bretz, JD
    Zhang, M
    Gentz, R
    Mann, M
    Krammer, PH
    Peter, ME
    Dixit, VM
    [J]. CELL, 1996, 85 (06) : 817 - 827
  • [10] Caspases: killer proteases
    Nicholson, DW
    Thornberry, NA
    [J]. TRENDS IN BIOCHEMICAL SCIENCES, 1997, 22 (08) : 299 - 306