The Stromal Niche for Epithelial Stem Cells: A Template for Regeneration and a Brake on Malignancy

被引：50
|
作者：
Roberts, Kelsey J. [1 ,3 ]
Kershner, Aaron M. [2 ,3 ]
Beachy, Philip A. [1 ,2 ,3 ]
机构：
[1] Stanford Univ, Sch Med, Dept Dev Biol, Stanford, CA 94305 USA
[2] Stanford Univ, Sch Med, Dept Biochem, Stanford, CA 94305 USA
[3] Stanford Univ, Sch Med, Inst Stem Cell Biol & Regenerat Med, Stanford, CA 94305 USA
来源：
CANCER CELL | 2017年 / 32卷 / 04期
关键词：
GROWTH-HORMONE DEFICIENCY; SELF-RENEWAL; PANCREAS DEVELOPMENT; BLADDER UROTHELIUM; PROSTATE-CANCER; HOST DEFENSES; WNT PROTEINS; IGF-I; HEDGEHOG; BASAL;
D O I：
10.1016/j.ccell.2017.08.007
中图分类号：
R73 [肿瘤学];
学科分类号：
100214 ;
摘要：
Stromal restraint of cancer growth and progression-emerging as a widespread phenomenon in epithelial cancers such as bladder, pancreas, colon, and prostate-appears rooted in stromal cell niche activity. During normal tissue repair, stromal niche signals, often Hedgehog-induced, promote epithelial stem cell differentiation as well as self-renewal, thus specifying a regenerating epithelial pattern. In the case of cancerous tissue, stromal cell-derived differentiation signals in particular may provide a brake on malignant growth. Understanding and therapeutic harnessing of the role of stroma in cancer restraint may hinge on our knowledge of the signaling programs elaborated by the stromal niche.
引用
收藏
页码：404 / 410
页数：7
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