Radiation-induced osteosarcoma arising 20 years after the treatment of Ewing's sarcoma

被引：8

作者：

Longhi, A ^{[1
]}

Barbieri, E ^{[1
]}

Fabbri, N ^{[1
]}

Macchiagodena, M ^{[1
]}

Favale, L ^{[1
]}

Lippo, C ^{[1
]}

Salducca, N ^{[1
]}

Bacci, G ^{[1
]}

机构：

[1] Ist Ortoped Rizzoli, Sez Chemioterapia, Dept Musculoskeletal Oncol, I-40136 Bologna, Italy

来源：

TUMORI | 2003年 / 89卷 / 05期

关键词：

Ewing's sarcoma; late side effects; post-radiation osteosarcoma;

D O I：

10.1177/030089160308900526

中图分类号：

R73 [肿瘤学];

学科分类号：

100214 ;

摘要：

We report the case of a 17 years old female with a Ewing's sarcoma of the left femur treated with limb sparing surgery followed by local radiotherapy of 45 Gy and adjuvant chemotherapy with vincristine, doxorubicine, cyclophosphamide, actinomycin D. The patient received neoadjuvant chemotherapy for osteosarcoma and a left femur resection with endoprosthesis replacement. The patient is alive and free of disease 4 years after the treatment of this second malignant neoplasm (SMN). This case shows that radioinduced SMN can occur with relatively low doses of RT (<50 Gy) and that it may occur very late.

引用

页码：569 / 572

页数：4

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