Ligand-free palladium-catalyzed cyanation of aryl halides

被引：214
|
作者：
Weissman, SA [1 ]
Zewge, D [1 ]
Chen, C [1 ]
机构：
[1] Merck & Co Inc, Merck Res Labs, Dept Proc Res, Rahway, NJ 07065 USA
来源：
JOURNAL OF ORGANIC CHEMISTRY | 2005年 / 70卷 / 04期
关键词：
D O I：
10.1021/jo0481250
中图分类号：
O62 [有机化学];
学科分类号：
070303 ; 081704 ;
摘要：
A practical, ligand-free cyanation of aryl bromides that utilizes as little as 0.1 mol % Pd(OAc)(2) in combination with a nontoxic cyanide source, M-4[Fe(CN)(6)] (M = K, Na), is described. The reactions are performed in DMAC at 120 degreesC and provide the corresponding aryl nitrile in 83-96% yield, typically in less than 5 h. TON values of up to 7100 were attained.
引用
收藏
页码：1508 / 1510
页数：3
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