SATB1 and colorectal cancer in Wnt/β-catenin signaling: Is there a functional link?

被引：11
|
作者：
Meng, Wen-Jian [1 ,2 ]
Yan, Hui [1 ,2 ]
Li, Yuan [2 ,3 ,4 ]
Zhou, Zong-Guang [1 ,2 ,4 ]
机构：
[1] Sichuan Univ, W China Hosp, Dept Gastrointestinal Surg, Chengdu 610064, Peoples R China
[2] Sichuan Univ, W China Hosp, Inst Digest Surg & Organ Microcirculat, Chengdu 610064, Peoples R China
[3] Sichuan Univ, W China Hosp, Dept Pediat Surg, Chengdu 610064, Peoples R China
[4] Sichuan Univ, W China Hosp, Natl Key Lab Biotherapy, Chengdu 610064, Peoples R China
来源：
MEDICAL HYPOTHESES | 2011年 / 76卷 / 02期
基金：
中国国家自然科学基金;
关键词：
BETA-CATENIN; EXPRESSION; GENE; MUTATIONS; OVEREXPRESSION; INSTABILITY; CHROMATIN;
D O I：
10.1016/j.mehy.2010.10.022
中图分类号：
R-3 [医学研究方法]; R3 [基础医学];
学科分类号：
1001 ;
摘要：
Colorectal cancer is the third most common malignant cancer worldwide and molecular mechanisms of cancer metastasis are poorly understood. Researches suggested that the canonical Wnt/beta-catenin signaling pathway plays a critical role in development and cancer. beta-catenin acts as a component of the Wnt signaling in addition to being an integral component of adherens junctions. The traditional notion that beta-catenin dysregulation caused by inactivating mutation of APC cannot completely elucidate the role of beta-catenin in invasion and metastasis. Recently, the important roles of SATB1 in T-cell development and differentiation and in promotion of breast tumor growth and metastasis were reported. The hypothesis we proposed is that SATB1 may be involved in the development and progression of colorectal cancer in a Wnt/beta-catenin signaling-dependent manner. (C) 2010 Published by Elsevier Ltd.
引用
收藏
页码：277 / 279
页数：3
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