Use of Ferulic Acid in the Management of Diabetes Mellitus and Its Complications

被引：31

作者：

Li, Xu ^{[1
]}

Wu, Jingxian ^{[2
]}

Xu, Fanxing ^{[1
,2
]}

Chu, Chun ^{[3
]}

Li, Xiang ^{[4
]}

Shi, Xinyi ^{[2
]}

Zheng, Wen ^{[2
]}

Wang, Zhenzhong ^{[1
]}

Jia, Ying ^{[5
]}

Xiao, Wei ^{[1
]}

机构：

[1] Jiangsu Kan Pharmaceut Co Ltd, Lianyungang 222001, Peoples R China

[2] Shenyang Pharmaceut Univ, Wuya Coll Innovat, Shenyang 110016, Peoples R China

[3] Shenyang Pharmaceut Univ, Sch Pharm, Shenyang 110016, Peoples R China

[4] Shenyang Pharmaceut Univ, Sch Pharmaceut Engn, Shenyang 110016, Peoples R China

[5] Shenyang Pharmaceut Univ, Fac Funct Food & Wine, Shenyang 110016, Peoples R China

来源：

MOLECULES | 2022年 / 27卷 / 18期

基金：

中国博士后科学基金; 中国国家自然科学基金;

关键词：

ferulic acid; diabetes mellitus; diabetic complications; HIGH-FAT DIET; ALDOSE REDUCTASE; ENDOTHELIAL DYSFUNCTION; TRANSCRIPTION FACTOR; OXIDATIVE STRESS; LIVER-INJURY; INSULIN; HYPERTENSION; EXPRESSION; RATS;

D O I：

10.3390/molecules27186010

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

Diabetes mellitus, a metabolic disease mainly characterized by hyperglycemia, is becoming a serious social health problem worldwide with growing prevalence. Many natural compounds have been found to be effective in the prevention and treatment of diabetes, with negligible toxic effects. Ferulic acid (FA), a phenolic compound commonly found in medicinal herbs and the daily diet, was proved to have several pharmacological effects such as antihyperglycemic, antihyperlipidemic and antioxidant actions, which are beneficial to the management of diabetes and its complications. Data from PubMed, EM-BASE, Web of Science and CNKI were searched with the keywords ferulic acid and diabetes mellitus. Finally, 28 articles were identified after literature screening, and the research progress of FA for the management of DM and its complications was summarized in the review, in order to provide references for further research and medical applications of FA.

引用

页数：13

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