From Prescription to Transcription: Genome Sequence as Drug Target

被引：6
|
作者：
Guo, Cong [1 ,2 ]
D'Ippolito, Anthony M. [1 ,2 ]
Reddy, Timothy E. [1 ,3 ]
机构：
[1] Duke Univ, Sch Med, Ctr Genom & Computat Biol, Durham, NC 27708 USA
[2] Duke Univ, Sch Med, Univ Program Genet & Genom, Durham, NC 27708 USA
[3] Duke Univ, Sch Med, Dept Biostat & Bioinformat, Durham, NC 27708 USA
来源：
CELL | 2015年 / 162卷 / 01期
关键词：
D O I：
10.1016/j.cell.2015.06.033
中图分类号：
Q5 [生物化学]; Q7 [分子生物学];
学科分类号：
071010 ; 081704 ;
摘要：
Personalizing treatments to account for genetically mediated differences in drug responses is an exciting opportunity to improve patient outcomes. In this issue, Soccio et al. reveal new mechanisms by which non-coding variants alter the activity of the anti-diabetic drug rosiglitazone.
引用
收藏
页码：16 / 17
页数：2
相关论文
共 50 条
  • [1] Using bioinformatics for drug target identification from the genome
    Jiang, ZR
    Zhou, YH
    AMERICAN JOURNAL OF PHARMACOGENOMICS, 2005, 5 (06) : 387 - 396
  • [2] Sequence basis of transcription initiation in the human genome
    Dudnyk, Kseniia
    Cai, Donghong
    Shi, Chenlai
    Xu, Jian
    Zhou, Jian
    SCIENCE, 2024, 384 (6694)
  • [3] Human genome sequence helps target cancer
    Incles, C
    CHEMISTRY WORLD, 2005, 2 (05): : 29 - 29
  • [4] Human genome sequence helps target cancer
    Incles, C
    ORGANIC & BIOMOLECULAR CHEMISTRY, 2005, 3 (09) : C37 - C37
  • [5] Genome Sequence Variability Predicts Drug Precautions and Withdrawals from the Market
    Lee, Kye Hwa
    Baik, Su Youn
    Lee, Soo Youn
    Park, Chan Hee
    Park, Paul J.
    Kim, Ju Han
    PLOS ONE, 2016, 11 (09):
  • [6] In vivo drug target discovery:: identifying the best targets from the genome
    Walke, DW
    Han, CS
    Shaw, J
    Wann, E
    Zambrowicz, B
    Sands, A
    CURRENT OPINION IN BIOTECHNOLOGY, 2001, 12 (06) : 626 - 631
  • [7] Deep generative model for drug design from protein target sequence
    Yangyang Chen
    Zixu Wang
    Lei Wang
    Jianmin Wang
    Pengyong Li
    Dongsheng Cao
    Xiangxiang Zeng
    Xiucai Ye
    Tetsuya Sakurai
    Journal of Cheminformatics, 15
  • [8] Deep generative model for drug design from protein target sequence
    Chen, Yangyang
    Wang, Zixu
    Wang, Lei
    Wang, Jianmin
    Li, Pengyong
    Cao, Dongsheng
    Zeng, Xiangxiang
    Ye, Xiucai
    Sakurai, Tetsuya
    JOURNAL OF CHEMINFORMATICS, 2023, 15 (01)
  • [9] DNA-SEQUENCE ORGANIZATION AND TRANSCRIPTION OF THE CHICKEN GENOME
    ARTHUR, RR
    STRAUS, NA
    BIOCHIMICA ET BIOPHYSICA ACTA, 1983, 741 (02) : 171 - 179
  • [10] Bacterial Transcription as a Target for Antibacterial Drug Development
    Ma, Cong
    Yang, Xiao
    Lewis, Peter J.
    MICROBIOLOGY AND MOLECULAR BIOLOGY REVIEWS, 2016, 80 (01) : 139 - 160
12345