The Genomic Relationship Between Primary Breast Carcinomas and Their Nodal Metastases

被引：6

作者：

Desouki, Mohamed M. ^{[2
]}

Liao, Shaoxi ^{[1
]}

Conroy, Jeffrey ^{[3
]}

Nowak, Norma J. ^{[3
]}

Shepherd, Lori ^{[4
]}

Gaile, Daniel P. ^{[4
]}

Geradts, Joseph ^{[1
,4
]}

机构：

[1] Duke Univ, Med Ctr, Dept Pathol, Durham, NC 27710 USA

[2] Med Univ S Carolina, Dept Pathol, Charleston, SC 29425 USA

[3] Roswell Pk Canc Inst, Dept Canc Genet, Buffalo, NY 14263 USA

[4] SUNY Buffalo, Dept Biostat, Buffalo, NY USA

来源：

CANCER INVESTIGATION | 2011年 / 29卷 / 04期

关键词：

Breast cancer; Metastasis; Copy number changes; Tumor genes; RECEPTOR COACTIVATOR; CANCER-CELLS; BCL-2; FAMILY; EXPRESSION; ACTIVATION; TUMORS; GENE; HETEROGENEITY; SUPPRESSORS; RCK/P54;

D O I：

10.3109/07357907.2011.568564

中图分类号：

R73 [肿瘤学];

学科分类号：

100214 ;

摘要：

We screened the whole tumor genome to identify DNA copy number gains and losses that discriminate between primary breast carcinomas (MP) and their nodal metastases (ML). Six candidate genes were confirmed by quantitative PCR to have differentially distributed copy number changes. Three of the genes (ERR gamma gamma, DDX6, and TIAM1) were more commonly amplified in nodal metastases. Principal component analysis revealed that MP-ML pairs varied markedly in their genomic divergence. The latter was larger in PR-negative tumors. Nodal metastases may form early or late in the development of breast carcinomas and PR-negative tumors may metastasize earlier or are genomically less stable.</.

引用

页码：300 / 307

页数：8

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