Synthesis and antimicrobial activity of N-(substituted)-N'-(2,3-dihydro2-oxido-5-benzoyl-1H-1,3,2-benzodiazaphosphol-2-yl) ureas

被引：0
|
作者：
Reddy, PVG [1 ]
Reddy, CS [1 ]
Raju, CN [1 ]
机构：
[1] Sri Venkateswara Univ, Coll Engn, Dept Chem, Tirupati 517502, Andhra Pradesh, India
来源：
CHEMICAL & PHARMACEUTICAL BULLETIN | 2003年 / 51卷 / 07期
关键词：
3,4-diamino benzophenone; isocyanatophosphonic dichloride; carbamidophosphorie acid dichloride;
D O I：
暂无
中图分类号：
R914 [药物化学];
学科分类号：
100701 ;
摘要：
N-(Substituted)-N'-(2,3-dihydro-5-benzoyl-2-oxido-1H-1,3,2-benzodiazaphosphol-2-yl) ureas were synthesized by reacting 3,4-diaminobenzophenone (4) with different chlorides of carbamidophosphoric acids (3) in the presence of triethylamine at 40-45degreesC. Their H-1-, C-13- and P-31-NMR spectral data are discussed. The title compounds were screened for antifungal and antibacterial activity against the fungi Aspergillus niger and Fusarium solani and bacteria Escherichia coli and Staphylococcus aureus. These compounds showed higher antibacterial activity when compared with antifungal activity.
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收藏
页码：860 / 863
页数：4
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