Perfluoroalkylation of Aryl-N,N-dimethyl Hydrazones Using Hypervalent Iodine(III) Reagents or Perfluoroalkyl Iodides

被引：37
|
作者：
Janhsen, Benjamin [1 ]
Studer, Armido [1 ]
机构：
[1] Westfalische Wilhelins Univ Munster, Organ Chem Inst, Corrensstr 40, D-48149 Munster, Germany
来源：
JOURNAL OF ORGANIC CHEMISTRY | 2017年 / 82卷 / 22期
基金：
欧洲研究理事会;
关键词：
COPPER-CATALYZED TRIFLUOROMETHYLATION; RADICAL TRIFLUOROMETHYLATION; FUNCTIONAL-GROUPS; FLUORINE; N; N-DIALKYLHYDRAZONES; ELECTRON; CHEMISTRY; ALKENES;
D O I：
10.1021/acs.joc.7b00934
中图分类号：
O62 [有机化学];
学科分类号：
070303 ; 081704 ;
摘要：
Radical trifluoromethylation of aryl N,N-dimethyl hydrazones using TBAI as an initiator and Togni's reagent as a trifluoromethyl, radical source is described. Cascades proceed via electron-catalysis; this approach is generally more applicable to hydrazone perfluoroalkylation. using perfluoroalkyl iodides as, the radical precursors in combination with a base under visible-light initiation.
引用
收藏
页码：11703 / 11710
页数：8
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