Understanding totipotency: A role for alternative splicing

被引：2
|
作者：
De Los Angeles, Alejandro [1 ]
Liu, Pentao [2 ,3 ]
机构：
[1] Yale Univ, Sch Med, Dept Psychiat, New Haven, CT USA
[2] Univ Hong Kong, Sch Biomed Sci Stem Cell & Regenerat Consortium, Li Ka Shing Fac Med, Hong Kong, Peoples R China
[3] Hong Kong Sci & Technol Pk, Ctr Translat Stem Cell Biol, Hong Kong, Peoples R China
来源：
DEVELOPMENTAL CELL | 2021年 / 56卷 / 12期
关键词：
STEM-CELLS; GENERATION;
D O I：
10.1016/j.devcel.2021.06.002
中图分类号：
Q2 [细胞生物学];
学科分类号：
071009 ; 090102 ;
摘要：
Totipotency refers to single cells' developmental capacity to form an entire organism. Understanding how totipotent stem cells form has implications for chimera generation. In a recent Cell study, Shen et al. (2021) report that inhibition of spliceosomes resets conventional pluripotent stem cells to a cellular state with totipotency features.
引用
收藏
页码：1697 / 1699
页数：3
相关论文
共 50 条
  • [1] Splicing inhibition unlocks human totipotency
    Nakhle, Jean
    [J]. NATURE METHODS, 2024, 21 (08) : 1411 - 1411
  • [2] Understanding alternative splicing: towards a cellular code
    Arianne J. Matlin
    Francis Clark
    Christopher W. J. Smith
    [J]. Nature Reviews Molecular Cell Biology, 2005, 6 : 386 - 398
  • [3] Understanding alternative splicing: Towards a cellular code
    Matlin, AJ
    Clark, F
    Smith, CWJ
    [J]. NATURE REVIEWS MOLECULAR CELL BIOLOGY, 2005, 6 (05) : 386 - 398
  • [4] The role of alternative splicing in lung cancer
    Xuelian Ning
    Zitong Fu
    Jing Zhang
    Shuangshu Gao
    Zihan Cui
    Mingqi Cong
    Qingyu Guo
    Xixi Sun
    Jing Li
    Minghui Zhang
    Shuoshuo Wang
    [J]. Cancer Chemotherapy and Pharmacology, 2023, 92 : 83 - 95
  • [5] The role of alternative splicing in lung cancer
    Ning, Xuelian
    Fu, Zitong
    Zhang, Jing
    Gao, Shuangshu
    Cui, Zihan
    Cong, Mingqi
    Guo, Qingyu
    Sun, Xixi
    Li, Jing
    Zhang, Minghui
    Wang, Shuoshuo
    [J]. CANCER CHEMOTHERAPY AND PHARMACOLOGY, 2023, 92 (02) : 83 - 95
  • [6] Computing the Role of Alternative Splicing in Cancer
    Liu, Zhaoqi
    Rabadan, Raul
    [J]. TRENDS IN CANCER, 2021, 7 (04): : 347 - 358
  • [7] Role of alternative splicing in fish immunity
    Wang, Yunchao
    Xu, Xinyi
    Zhang, Ailong
    Yang, Shuaiqi
    Li, Hongyan
    [J]. FISH & SHELLFISH IMMUNOLOGY, 2024, 149
  • [8] Cyclooxygenase variants: The role of alternative splicing
    Roos, KLT
    Simmons, DL
    [J]. BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS, 2005, 338 (01) : 62 - 69
  • [9] Role of promoters in regulating alternative splicing
    Kolathur, Kiran Kumar
    [J]. GENE, 2021, 782
  • [10] The role of alternative splicing in the secretory pathway
    不详
    [J]. JOURNAL OF CELL SCIENCE, 2019, 132 (08)
12345