Regulation of Muscle Satellite Cell Function in Tissue Homeostasis and Aging

被引：29
|
作者：
Sacco, Alessandra [1 ]
Puri, Pier Lorenzo [1 ,2 ]
机构：
[1] Sanford Burnham Med Res Inst, Dev Aging & Regenerat Program, La Jolla, CA 92037 USA
[2] IRCCS Fdn Santa Lucia, Epigenet & Regenerat Med, Rome, Italy
来源：
CELL STEM CELL | 2015年 / 16卷 / 06期
关键词：
SKELETAL-MUSCLE; REJUVENATION; QUIESCENCE; ADULT; MICE;
D O I：
10.1016/j.stem.2015.05.007
中图分类号：
Q813 [细胞工程];
学科分类号：
摘要：
Age-related muscle decline is associated with functional impairment of satellite cells (SCs). Conflicting data suggest dysregulation of cell-extrinsic or - intrinsic factors can independently contribute to such impairment. Here, we emphasize the importance of identifying nodes that integrate these factors into feed-forward circuits, which could provide targets for therapeutic intervention.
引用
收藏
页码：585 / 587
页数：3
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