The role of chemokines and their receptors in dendritic cell biology

被引：39
|
作者：
Lukacs-Kornek, Veronika [1 ]
Engel, Daniel [1 ]
Tacke, Frank [2 ]
Kurts, Christian [1 ]
机构：
[1] Univ Bonn, Inst Mol Med & Expt Immunol, D-53105 Bonn, Germany
[2] RWTH Univ Hosp Aachen, Med Clin 3, Aachen, Germany
来源：
FRONTIERS IN BIOSCIENCE-LANDMARK | 2008年 / 13卷
关键词：
dendritic cells; chemokines; chemokine receptors; cell migration; endocytosis; T cell activation; immune escape mechanism; cell lineage; monocyte; Th1; Th2; differentiation; review;
D O I：
10.2741/2838
中图分类号：
Q5 [生物化学]; Q7 [分子生物学];
学科分类号：
071010 ; 081704 ;
摘要：
Dendritic cells ( DCs) are the chief inducers of adaptive immunity. Their normal life cycle begins with the generation of their precursors in the bone-marrow, followed by their release into the blood stream, continues with their entry into non-lymphoid tissues and commences with steady-state or infection-induced migration into draining lymph nodes. Each of these migration steps is controlled by distinct chemokine-chemokine receptor interactions, facilitated by dynamic changes in chemokine receptor expression. In this review, we describe current knowledge on the role of chemokines and their receptors in the control of DC migratory behavior, as well as other influences on DC biology.
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收藏
页码：2238 / 2252
页数：15
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