Terahertz solid immersion microscopy for sub-wavelength-resolution imaging of biological objects and tissues

被引：7

作者：

Chernomyrdin, Nikita V. ^{[1
]}

Kucheryavenko, Anna S. ^{[1
]}

Malakhov, Kirill M. ^{[1
]}

Schadko, Alexander O. ^{[1
]}

Komandin, Gennady A. ^{[2
]}

Lebedev, Sergey P. ^{[2
]}

Dolganova, Irina N. ^{[1
]}

Kurlov, Vladimir N. ^{[3
]}

Lavrukhin, Denis V. ^{[4
]}

Ponomarev, Dmitry S. ^{[4
]}

Yurchenko, Stanislav O. ^{[1
]}

Tuchinef, Valery V. ^{[5
,6
,7
]}

Zaytsev, Kirill I. ^{[1
,2
]}

机构：

[1] Bauman Moscow State Tech Univ, Moscow 105005, Russia

[2] RAS, AM Prokhorov Gen Phys Inst, Moscow 119991, Russia

[3] RAS, Inst Solid State Phys, Chernogolovka 142432, Russia

[4] RAS, Inst Ultra High Frequency Semicond Elect, Moscow 117105, Russia

[5] Saratov NG Chernyshevskii State Univ, Saratov 410012, Russia

[6] RAS, Inst Precis Mech & Control, Saratov 410028, Russia

[7] Tomsk State Univ, Tomsk 634050, Russia

来源：

SARATOV FALL MEETING 2017: OPTICAL TECHNOLOGIES IN BIOPHYSICS AND MEDICINE XIX | 2018年 / 10716卷

基金：

俄罗斯科学基金会;

关键词：

terahertz imaging; solid immersion lens; solid immersion microscopy; sub-wavelength resolution; biological tissues; PULSED SPECTROSCOPY; EX-VIVO; SYSTEM; RANGE;

D O I：

10.1117/12.2314464

中图分类号：

Q6 [生物物理学];

学科分类号：

071011 ;

摘要：

We have developed a method of terahertz (THz) solid immersion microscopy for imaging of biological objects and tissues. It relies on the solid immersion lens (SIL) employing the THz beam focusing into the evanescent-field volume and allowing strong reduction in the dimensions of the THz beam caustic. By solving the problems of the sample handling at the focal plane and raster scanning of its surface with the focused THz beam, the THz SIL microscopy has been adapted for imaging of soft tissues. We have assembled an experimental setup based on a backward-wave oscillator, as a continuous-wave source operating at the wavelength of lambda = 500 mu m, and a Golay cell, as a detector of the THz wave intensity. By imaging of the razor blade, we have demonstrated advanced 0.2 lambda-resolution of the proposed THz SIL configuration. Using the experimental setup, we have performed THz imaging of a mint leaf revealing its sub-wavelength features. The observed results highlight a potential of the THz SIL microscopy in biomedical applications of THz science and technology.

引用

页数：7

共 50 条

[1] Sub-wavelength-resolution imaging of biological tissues using THz solid immersion microscopy
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