Expression of equilibrative nucleoside transporter type 1 protein in elderly patients with schizophrenia

被引：14
|
作者：
Shan, Dan [1 ]
Haroutunian, Vahram [2 ]
Meador-Woodruff, James H. [1 ,3 ]
McCullumsmith, Robert E. [1 ]
机构：
[1] Univ Alabama Birmingham, Dept Psychiat & Behav Neurobiol, Sch Med, Civitan Int Res Ctr, Birmingham, AL 35294 USA
[2] Mt Sinai Sch Med, Dept Psychiat, New York, NY USA
[3] Univ Arizona, Evelyn F McKnight Brain Inst, Tucson, AZ USA
来源：
NEUROREPORT | 2012年 / 23卷 / 04期
关键词：
adenosine; equilibrative nucleoside transporter 1; excitatory amino acid transporter; glutamate; schizophrenia; GLUTAMATE; CORTEX; TRAFFICKING; RECEPTORS; DISORDER; THALAMUS; ENT1;
D O I：
10.1097/WNR.0b013e3283500987
中图分类号：
Q189 [神经科学];
学科分类号：
071006 ;
摘要：
Alterations in glutamatergic neurotransmission are thought to be involved in several psychiatric disorders, including schizophrenia. Equilibrative nucleoside transporter type 1 (ENT1) regulates glutamate levels by regulating excitatory amino acid transporter expression and activity in the brain. In this study, we investigated whether ENT1 is abnormally expressed in the brain of elderly patients with schizophrenia. We measured protein expression of ENT1 in the superior temporal gyrus (STG) and anterior cingulate cortex (ACC) in patients with schizophrenia (STG, n = 22; ACC, n = 34) and a comparison group (STG, n = 24; ACC, n = 29). We found decreased ENT1 expression in the STG in patients with schizophrenia, supporting the hypothesis of altered glutamate transport in this illness. NeuroReport 23:224-227 (C) 2012 Wolters Kluwer Health vertical bar Lippincott Williams & Wilkins.
引用
收藏
页码：224 / 227
页数：4
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